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238. Tateda Y, Ikeda R, Kakuta R, Ono J, Izuhara K, Ogawa T, Ise K, Shimada H, Murakami K, Murakami K, Nakamura Y, Katori Y, Ohta N

Expression of periostin in vocal fold polyps
Tohoku Journal of Experimental Medicine, in press

237. Rabe KF, FitzGerald JM, Bateman ED, Castro M, Pavord ID, Maspero JF, Busse WW, Izuhara K, Daizadeh N, Ortiz B, Pandit-Abid N, Rowe PJ, Deniz Y

Dupilumab is effective in patients with moderate-to-severe uncontrolled GINA-defined type 2 asthma irrespective of an allergic asthma phenotype
Journal of Allergy and Clinical Immunology: In Practice, in press

236. Takai M, Ono J, Okamoto M, Fujimoto K, Kamei A, Nunomura S, Nanri Y, Ohta S, Hoshino T, Azuma A, Izuhara K

Establishment of a novel ELISA system for measuring periostin independently of formation of the IgA complex
Annals of Clinical Biochemistry, in press

235. Kimura H, Shimizu K, Tanabe N, Makita H, Taniguchi N, Kimura H, Suzuki M, Abe Y, Matsumoto-Sasaki M, Oguma A, Sato M, Takei N, Matsumoto M, Goudarzi H, Sato S, Ono J, Izuhara K, Hirai T, Nishimura M, Konno S.

Further evidence for association of YKL-40 with severe asthma airway remodeling
Annals of Allergy, Asthma & Immunology, 128, 682-688, 2022

234. Yoshida T, Nagaoka T, Nagata Y, Suzuki Y, Tsutsumi T, Kuriyama S, Watanabe J, Togo S, Takahashi F, Matsushita M, Joki Y, Konishi H, Nunomura S, Izuhara K, Conway SJ, Takahashi K.

Periostin-related progression of different types of experimental pulmonary hypertension: A role for M2 macrophage and FGF-2 signaling
Respirology, 27, 529-538, 2022

233. Go H, Ono J, Ohto H, Nollet KE, Sato K, Kume Y, Maeda H, Chishiki M, Haneda K, Ichikawa H, Kashiwabara N, Kanai Y, Ogasawara K, Sato M, Hashimoto K, Nunomura S, Izuhara K, Hosoya M.

In search of biomarkers: Can serum periostin predict bronchopulmonary dysplasia in premature infants?
Pediatric Research, in press

232. Hirayama J, Fujisawa1 T, Nagao M, Kuwabara Y, Kainuma K, Azuma Y, Ono J, Ohta S, Hirayama M, Izuhara K.

Squamous cell carcinoma antigens (SCCAs) are sensitive biomarkers for atopic dermatitis in children and adolescents: a cross-sectional study.
Asia Pacific Allergy, 11, e42, 2021

231. Nanri Y, Nunomura S, Watanabe T, Ohta S, Yamaguchi Y, Izuhara K.

Expression profile of periostin isoforms in systemic sclerosis.
Journal of Dermatological Science, 104, 210-212, 2021

230. Pfaar O, Blumchen K, Boateng E, Hamelmann E, Iinuma T, Jakob T, Krauss-Etschmann S, Nagase H, Nakajima S, Nakano T, Renz H, Sato S, Taube C, Wagenmann M, Werfel T, Worm M, Izuhara K.

Precision medicine reaching out to the patients in allergology- a German-Japanese workshop report.
Allergologie select, 5, 162-179, 2021.

229. Ono J, Takai M, Kamei A, Azuma Y, Izuhara K.

Pathological roles and clinical usefulness of periostin in type 2 inflammation and pulmonary fibrosis.
Biomolecules, 11, 1084, 2021.

228. Kitaya S, Ohta N, Kitaya S, Yuta A, Ogawa Y, Suzuki Y, Ichihara S, Enomoto T, Kozaki H, Shimizu T, Ono J, Izuhara K, Okamoto Y.

Serum concentrations of antigen-specific IgG4 in patients with Japanese cedar pollinosis.
Allergies, 1, 140-149, 2021.

227. Iwamoto R, Tanoue S, Nagata S, Tabata K, Fukuoka J, Koganemaru M, Sumi A, Chikasue T, Abe T, Murakami D, Takamori S, Ishii H, Ohshima K, Ohta S, Izuhara K, Fujimoto.

T1 invasive lung adenocarcinoma: Thin-section CT solid score and histological periostin expression predict tumor recurrence.
Molecular and Clinical Oncology, 15, 228, 2021.

226. Nunomura S, Kitajima I, Nanri Y, Kitajima M, Ejiri N, Lai IS, Okada N, Izuhara K.

The FADS mouse: A novel mouse model of atopic keratoconjunctivitis.
Journal of Allergy and Clinical Immunology, 148, 1596-1602.E1, 2021.

225. Shimizu H, Sakamoto S, Okamoto M, Isshiki T, Ono J, Shimizu S, Hoshino T, Izuhara K, Homma S.

Association of serum monomeric periostin level with outcomes of acute exacerbation of idiopathic pulmonary fibrosis and fibrosing nonspecific interstitial pneumonia.
Annals of Translational Medicine, 9, 739, 2021.

224. Kurokawa R, Kanemitsu Y, Fukumitsu K, Takeda N, Yap J, Ozawa Y, Masaki A, Ono J, Izuhara K, Nishiyama H, Fukuda S, Uemura T, Tajiri T, Ohkubo H, Maeno K, Ito Y, Oguri T, Takemura M, Suzuki M, Niimi A.

Nasal polyp eosinophilia and FeNO may predict asthma symptoms development after endoscopic sinus surgery in CRS patients without asthma.
Journal of Asthma, 59, 1139-1147, 2022.

223. Nunomura S, Nanri Y, Lefebvre V, Izuhara K.

Epithelial SOX11 regulates eyelid closure during embryonic eye development.
Biochemical and Biophysical Research Communications, 549, 27-33, 2021.

222. Delgado-Eckert E, James A, Meier-Girard D, Kupczyk M, Andersson LI, Bossios A, Mikus M, Ono J, Izuhara K, Middelveld R, Dahlén B, Gaga M, Siafakas NM, Papi A, Beghe B, Joos G, Rabe KF, Sterk PJ, Bel EH, Johnston SL, Chanez P, Gjomarkaj M, Howarth PH, Ni?ankowska-Mogilnicka E, Dahlén S-E, Frey.

Lung function fluctuation patterns unveil asthma and COPD phenotypes unrelated to type 2 inflammation.
Journal of Allergy and Clinical Immunology, 148, 407-419, 2021.

221. Sunadome H, Matsumoto H, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Iwanaga T, Hozawa S, Niimi A, Kanemitsu Y, Nagasaki T, Tashima N, Ishiyama Y, Morimoto C, Oguma T, Tajiri T, Ito I, Ono J, Ohta S, Izuhara K, Hirai T.

Assessment of serum periostin level as a predictor of requirement for intensive treatment for type-2 inflammation in asthmatics in future: A follow-up study of the KiHAC cohort.
Allergology International, 70, 252-254, 2021.

220. Morimoto C, Matsumoto H, Tajiri T, Gon Y, Ito R, Hashimoto S, Suzukawa M, Ohta K, Izuhara K, Ono J, Ohta S, Ito I, Oguma T, Kanemitsu Y, Nagasaki T, Izuhara Y, Niimi A, Hirai T.

High serum free IL-18 level is associated with decreased omalizumab efficacy: findings from a 2-year omalizumab treatment study.
Journal of Asthma, 58, 1133-1142, 2021.

219. Kanemitsu Y, Fukumitsu K, Kurokawa R, Takeda N, Ozawa Y, Masaki A, Ono J, Izuhara K, Yap J, Nishiyama H, Fukuda S, Uemura T, Tajiri T, Ohkubo H, Maeno K, Ito Y, Oguri T, Takemura M, Suzuki M, Niimi A.

Moulds and Staphylococcus aureus enterotoxins are relevant allergens to affect type2 inflammation and clinical outcomes in CRS patients.
ERJ Open Research, 6, 00265-2020, 2020.

218. Nakahara T, Izuhara K, Onozuka D, Nunomura S, Tamagawa-Mineoka R, Masuda K, Ichiyama S, Saeki H, Kabata Y, Abe R, Ohtsuki M, Kamiya K, Okano T, Miyagaki T, Ishiuji Y, Asahina A, Kawasaki H, Tanese K, Mitsui H, Kawamura T, Takeichi T, Akiyama M, Nishida E, Morita A, Tonomura K, Nakagawa Y, Sugawara K, Tateishi C, Kataoka Y, Fujimoto R, Kaneko S, Morita E, Tanaka A, Hide M, Aoki N, Sano S, Matsuda-Hirose H, Hatano Y, Takenaka M, Murota H, Katoh N, Furue.

Biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab (B-PAD study): study protocol.
Medicine, 99, e22043, 2020.

217. Isshiki T, Matsuyama H, Yamaguchi T, Morita T, Ono J, Nunomura S, Izuhara K, Sakamoto S, Homma S, Kishi K.

Plasma matrix metalloproteinase 7, CC-chemokine ligand 18, and periostin as markers for pulmonary sarcoidosis.
Respiratory Investigation, 58, 479-487, 2020.

216. Kanemitsu Y, Kurokawa R, Ono J, Fukumitsu K, Takeda N, Fukuda S, Uemura T, Tajiri T, Ohkubo H, Maeno K, Ito Y, Oguri T, Takemura M, Yap J, Nishiyama H, Masaki A, Ozawa Y, Izuhara K, Suzuki M, Niimi A.

Increased serum periostin levels and eosinophils in nasal polyps are associated with the preventive effect of endoscopic sinus surgery for asthma exacerbations in chronic rhinosinusitis patients.
International Archives of Allergy and Immunology, 181, 862-870, 2020.

215. Tanosaki T, Kabata H, Matsusaka M, Miyata J, Masaki K, Mochimaru T, Okuzumi S, Kuwae M, Watanabe R, Suzuki Y, Sayama K, Izuhara K, Asano K, Fukunaga T.

Clinical characteristics of patients with not well-controlled severe asthma in Japan: analysis of the Keio Severe Asthma Research Program in Japanese Population (KEIO-SARP) registry.
Allergology International, 70, 61-67, 2021.

214. Sunadome H, Matsumoto H, Tachikawa R, Matsumoto T, Tanizawa K, Oga T, Ono J, Ohta S, Izuhara K, Hirai T, ChinT.

Role of serum periostin in severe obstructive sleep apnea with albuminuria.
Respiratory Research, 21, 143, 2020.

213. Asano T, Ohbayashi H, Ariga M, Furuta O, Kudo S, Ono J, Izuhara K.

Serum periostin reflects dynamic hyperinflation in patients with asthma.
ERJ Open Research, 6, 00347-2019, 2020.

212. Hayashi H, Fukutomi Y, Mitsui C, Kajiwara K, Watai K, Kamide Y, Nakamura Y, Hamada Y, Tomita Y, Sekiya K, Tsuburai T, Izuhara K, Wakahara K, Hashimoto N, Hasegawa Y, Taniguchi M.

Omalizumab for aspirin-hypersensitivity and leukotriene overproduction in aspirin- exacerbated respiratory disease: A randomized trial.
American Journal of Respiratory and Critical Care Medicine, 201, 1488-1498, 2020.

211. Matsunaga K, Katoh N, Fujieda S, Izuhara K, Oishi K.

Dupilumab: Basic aspects and applications to allergic diseases.
Allergology International, 69, 187-196, 2020.

210. Tanaka J, Hebisawa A, Oguma T, Tomomatsu K, Suzuki J, Shimizu H, Kawabata Y, Ishiguro T, Takayanagi N, Ueda S, Fukunaga K, Taniguchi M, Ono J, Ohta S, Izuhara K, Asano K.

Evaluating serum periostin levels in allergic bronchopulmonary aspergillosis.
Allergy, 75, 974-977, 2020.

209. Yoshihara T, Nanri Y, Nunomura S, Yamaguchi Y, Feghali-Bostwick C, Ajito K, Murakami S, Mawatari M, Izuhara K.

Periostin plays a critical role in the cell cycle in lung fibroblasts.
Respiratory Research, 21, 38, 2020.

208. Kanemitsu Y, Suzuki M, Fukumitsu K, Asano T, Takeda N, Nakamura Y, Ozawa Y, Masaki A, Ono J, Kurokawa R, Yap J, Nishiyama H, Fukuda S, Ohkubo H, Maeno K, Ito Y, Oguri T, Izuhara K, Takemura M, Niimi A.

A novel pathophysiologic link between upper and lower airways in patients with chronic rhinosinusitis: Association of sputum periostin levels with upper airway inflammation and olfactory function.
World Allergy Organization Journal, 13, 10094, 2020.

207. Oka A, Ninomiya T, Fujiwara T, Takao S, Sato Y, Gion Y, Minoura A, Haruna S, Yoshida N, Sakuma Y, Izuhara K, Ono J, Taniguchi M, Haruna T, Higaki T, Kariya S, Koyama T, Takabayashi T, Imoto Y, Sakashita M, Kidoguchi M, Nishizaki K, Fujieda S, Okano.

Serum IgG4 as a biomarker in chronic rhinosinusitis.
Allergology International, 69, 417-423, 2020

206. Mitamura Y, Nunomura S, Furue M, Izuhara K.

IL-24: A new player in the pathogenesis of proinflammatory and allergic skin diseases.
Allergology International, 69, 405-411,2020.

205. Nanri Y, Nunomura S, Terasaki Y, Yoshihara T, Hirano Y, Yokosaki Y, Yamaguchi Y, Feghali-Bostwick C, Ajito K, Murakami S, Conway SJ, Izuhara K.

The Cross-talk Between TGF-b and periostin can be targeted for pulmonary fibrosis.
American Journal of Respiratory Cell and Molecular Biology ,62, 204-216, 2020.

204. Ono J, Takai M, Kamei A, Nunomura S, Nanri Y, Yoshihara T, Ohta S, Yasuda K, Conway SJ, Yokosaki Y, Izuhara K.

Periostin forms a functional complex with IgA in human.
Allergology International, 69, 111-120, 2020

203. Okamoto M, Izuhara K, Ohta S, Ono J, Hoshino T.

Ability of periostin as a new biomarker of idiopathic pulmonary fibrosis.
Adv Exp Med Biol, 1132, 79-87, 2019

202. Sung M, Baek H, Yeon D, Lee S, Ha E, Lee K, Jee H, Sheen Y, Ono J, Izuhara K, Han M.

Serum periostin level has limited usefulness as a biomarker for allergic disease in 7-year-old children.
International Archives of Allergy and Immunology, 180, 195-201, 2019

201. Izuhara K, Nunomura S, Nanri Y, Ono J, Takai M, Kawaguchi A.

Periostin: An emerging biomarker for allergic diseasest.
Allergy, 74, 2116-2128, 2019

200. Takeuchi S, Furusyo N, Ono J, Azuma Y, Takemura M, Esaki H, Yamamura K, Mitamura Y, Tsuji G, Kiyomatsu-Oda M, Hayashi J, Izuhara K, Furue M.

Serum squamous cell carcinoma antigen (SCCA)-2 correlates with clinical severity of pediatric atopic dermatitis in Ishigaki cohort.
Journal of Dermatological Science, 95, 70-75, 2019

199. Ohta N, Fukase S, Kusano Y, SaitoY, Tateda Y, Ishida Y, Ikeda R, Yamazaki M, Ono J, Izuhara K.

Treatment of auricular hematomas by OK-432: How and why it works.
Otology & Neurotology, 40, e820-e823, 2019

198. Ito R, Maruoka S, Gon Y, Katano I, Takahashi T, Ito M, Izuhara K, Nunomura S.

Recent advances in allergy research using humanized mice.
Int J Mol Sci, 20, E2740, 2019

197. Nukui Y, Miyazaki Y, Masuo M, Okamoto T, Furusawa H, Tateishi T, Kishino M, Tateishi U, Ono J, Ohta S, Izuhara K, Inase N.

Periostin as a predictor of prognosis in chronic bird-related hypersensitivity pneumonitis.
Allergology International, 68, 363-369, 2019

196. Koga Y, Hachisu Y, Tsurumaki H, Yatomi M, Kaira K, Ohta S, Ono J, Izuhara K, Dobashi K, Hisada T.

Pirfenidone Improves Familial Idiopathic Pulmonary Fibrosis without Affecting Serum Periostin Levels.
Medicina, 55, E161, 2019

195. Agache I, Jutel M, Lau S, Akdis CA, Bonini M, Cavkaytar O, Flood B,  Gajdanowicz P, Izuhara K, Kalayci Ö, Mosges R, Palomares O, Papadopoulos N, Smolinska S, Sokolowska M, Angiers E, Fernandes-RM, Halken S, Pajno G, Pfaar O , Roberts G, Ryan D, Sturm G, Ree Rv, Varga EM, Wijk RGv, Dhami S, Sheikh A, Muraro A.

EAACI guidelines on allergen immunotherapy: House dust mite-driven allergic asthma.
Allergy, 74, 855-873, 2019

194. Fujitani H, Kasuga S, Ishihara T, Higa Y, Fujikawa S, Ohta N, Ono J, Izuhara K,  Shintaku H.

Age-related changes in serum periostin level in allergic and non-allergic children.
Allergology International, 68, 285-286, 2019

193. Takahashi K, Meguro K, Kawashima H, Kashiwakuma D, Kagami S, Ohta S, Ono J, Izuhara K, Iwamoto I.

Serum periostin levels serve as a biomarker for both eosinophilic airway inflammation and fixed airflow limitation in well-controlled asthmatics.
Journal of Asthma, 56, 236-243, 2019

192. Cho JH, Kim K, Yoon JW, Choi SH, Sheen YH, Han M, Ono J, Izuhara K, Baek H.
Serum levels of periostin and exercise-induced bronchoconstriction in asthmatic children.
World Allergy Organization Journal, 12, 100004, 2019

191. Nunomura S, Ejiri N, Kitajima M, Nanri Y, Arima K, Mitamura Y, Yoshihara T, Fujii K, Takao K, Imura J, Fehling HJ, Izuhara K, Kitajima I.
Establishment of a Mouse Model of Atopic Dermatitis by Deleting Ikk2 in Dermal Fibroblasts.
J Invest Dermatol, 139, 1274-1283, 2019

190. Mogensen I, Alving K, Dahlen SE, James A, Forsberg B, Ono J, Ohta S, Venge P, Borres MP, Izuhara K, Janson C, Malinovschi A.
Fixed airflow obstruction relates to eosinophil activation in asthmaticsn.
Clin Exp Allergy, 49, 152-162, 2019

189. Ohno F, Nakahara T, Kido-Nakahara M, Ito T, Nunomura S, Izuhara K, Furue M.
Periostin Links Skin Inflammation to Melanoma Progression in Humans and Mice.
Int J Mol Sci, 20, pii: E169, 2019

188. Nakagome K, Nakamura Y, Kobayashi T, Ohta S, Ono J, Kobayashi K, Ikebuchi K, Noguchi T, Soma T, Yamauchi K, Izuhara K, Nagata M.
Elevated Periostin Concentrations in the Bronchoalveolar Lavage Fluid of Patients with Eosinophilic Pneumonia.
Int Arch Allergy Immunol, 178, 264-271, 2019

187. Yasuda M, Harada N, Harada S, Ishimori A, Katsura Y, Itoigawa Y, Matsuno K, Makino F, Ito J, Ono J, Tobino K, Akiba H, Atsuta R, Izuhara K, Takahashi K.
Characterization of tenascin-C as a novel biomarker for asthma: utility of tenascin-C in combination with periostin or immunoglobulin E.
Allergy Asthma Clin Immunol, 14, 72, 2018

186. Lee JH, Kim SH, Choi Y, Trinh HKT, Yang EM, Ban GY, Shin YS, Ye YM, Izuhara K, Park HS.
Serum Periostin Levels: A Potential Serologic Marker for Toluene Diisocyanate-Induced Occupational Asthma.
Yonsei Med J, 59,1214-1221, 2018

185. Ito R, Maruoka S, Soda K, Katano I, Kawai K, Yagoto M, Hanazawa A, Takahashi T, Ogura T, Goto M, Takahashi R, Toyoshima S, Okayama Y, Izuhara K, Gon Y, Hashimoto S, Ito M, Nunomura S.
A humanized mouse model to study asthmatic airway inflammation via the human IL-33/IL-13 axis.
JCI Insight, 3, pii: 121580, 2018

184. Yon DK, An J, Ha EK, Jee HM, Izuhara K, Ono J, Jung YH, Lee KS, Sheen YH, Baek H, Han MY.
Serum Periostin Is Negatively Correlated With Exposure to Formaldehyde and Volatile Organic Compounds in Children.
Allergy Asthma Immunol Res, 10, 716-721, 2018

183. Murata K, Koga Y, Kasahara N, Hachisu Y, Nunomura S, Nakajima N, Yokoo H, Kaira K, Maeno T, Dobashi K, Izuhara K, Hisada T.
Accumulation of periostin in acute exacerbation of familial idiopathic pulmonary fibrosis.
J Thorac Dis, 10, E587-E591, 2018

182. Ninomiya T, Noguchi E, Haruna T, Hasegawa M, Yoshida T, Yamashita Y, Okano M, Yoshida N, Haruna S, Sakuma Y, Ohta S, Ono J, Izuhara K, Okada M, Kidoguchi M, Tokunaga T, Okamoto M, Kanno M, Sakashita M, Takabayashi T, Narita N, Fujieda S.
Periostin as a novel biomarker for postoperative recurrence of chronic rhinosinitis with nasal polyps.
Sci Rep, 8, 11450, 2018

181. Mitamura Y, Nunomura S, Nanri Y, Arima K, Yoshihara T, Komiya K, Fukuda S, Takatori H, Nakajima H, Furue M, Izuhara K.
Hierarchical control of interleukin13 (IL-13) signals in lung fibroblasts by STAT6 and SOX11.
J Biol Chem, 293, 14646-14658, 2018

180. Mitamura Y, Nunomura S, Nanri Y, Ogawa M, Yoshihara T, Masuoka M, Tsuji G, Nakahara T, Hashimoto-Hachiya A, Conway SJ, Furue M, Izuhara K.
The IL-13/periostin/IL-24 pathway causes epidermal barrier dysfunction in allergic skin inflammation.
Allergy, 73, 1881-1891, 2018

179. Nagao M, Inagaki S, Kawano T, Azuma Y, Nomura N, Noguchi Y, Ohta S, Kawaguchi A, Odajima H, Ohya Y, Fujisawa T, Izuhara K.
SCCA2 is a reliable biomarker for evaluating pediatric atopic dermatitis.
J Allergy Clin Immunol, 141,1934-1936.e11, 2018

178. Semba T, Sugihara E, Kamoshita N, Ueno S, Fukuda K, Yoshino M, Takao K, Yoshikawa K, Izuhara K, Arima Y, Suzuki M, Saya H.
Periostin antisense oligonucleotide suppresses bleomycin-induced formation of a lung premetastatic niche for melanoma
Cancer Sci, 109, 1447-1454, 2018

177. Izuhara K, Yamaguchi Y, Ohta S, Nunomura S, Nanri Y, Azuma Y, Nomura N, Noguchi Y, Aihara M.
Squamous Cell Carcinoma Antigen 2 (SCCA2, SERPINB4): An Emerging Biomarker for Skin Inflammatory Diseases.
Int J Mol Sci, 19(4), pii: E1102, 2018

176. Kanaoka M, Yamaguchi Y, Komitsu N, Feghali-Bostwick CA, Ogawa M, Arima K, Izuhara K, Aihara M.
Pro-fibrotic phenotype of human skin fibroblasts induced by periostin via modulating TGF-β signaling
J Dermatol Sci, 90, 199-208, 2018

175. Takahashi K, Meguro K, Kawashima H, Kashiwakuma D, Kagami SI, Ohta S, Ono J, Izuhara K, Iwamoto I.
Serum periostin levels serve as a biomarker for both eosinophilic airway inflammation and fixed airflow limitation in well-controlled asthmatics.
J Asthma, 12, 1-8, 2018

174. Nunomura S, Nanri Y, Ogawa M, Arima K, Mitamura Y, Yoshihara T, Hasuwa H, Conway SJ, Izuhara K.
Constitutive overexpression of periostin delays wound healing in mouse skin.
Wound Repair Regen, 26, 6-15, 2018

173. Kimura H, Konno S, Makita H, Taniguchi N, Kimura H, Goudarzi H, Shimizu K, Suzuki M, Shijubo N, Shigehara K, Ono J, Izuhara K, Ito YM, Nishimura M.
Serum periostin is associated with body mass index and allergic rhinitis in healthy and asthmatic subjects.
Allergology International, 67, 357-363, 2018

172. Matsusaka M, Kabata H, Fukunaga K, Izuhara K, Asano K, Betsuyaku TD
Sub-phenotypes of type 2 severe asthma in adults
J Allergy Clin Immunol: In Practice, 6, 274-276.e2., 2018

171. Okawa T, Yamaguchi Y, Kou K, Ono J, Azuma Y, Komitsu N, Inoue Y, Kohno M, Matsukura S, Kambara T, Ohta S, Izuhara K, Aihara MD
Serum levels of squamous cell carcinoma antigens 1 and 2 reflect disease severity and clinical type of atopic dermatitis in adult patients
Allergology International, 67, 124-130, 2018

170. Izuhara K, Suzuki S, Ogawa M, Nunomura S, Nanri Y, Mitamura Y, Yoshihara T.
The Significance of Hypothiocyanite Production via the Pendrin/DUOX/Peroxidase Pathway in the Pathogenesis of Asthma.
Oxidative Medicine and Cellular Longevity, 1054801,2017.

169. Nakamura H, Akashi K, Watanabe M, Ohta S, Ono J, Azuma Y, Ogasawara N, Yamamoto K, Shimizu N, Tsutsumi H, Izuhara K, Katsunuma T.
Up-regulation of serum periostin and squamous cell carcinoma antigen levels in infants with acute bronchitis due to respiratory syncytial virus.
Allergology International, 67, 259-265, 2018

168. Agache I, Strasser DS, Pierlot GM, Farine H, Izuhara K, Akdis CA.
Monitoring inflammatory heterogeneity with multiple biomarkers for multidimensional endotyping of asthma.
J Allergy Clin Immunol, 141, 442-445, 2018

167. Mino M, Kanno K, Okimoto K, Sugiyama A, Kishikawa N, Kobayashi T, Ono J, Izuhara K, Kobayashi T, Ohigashi T, Ohdan H, Tazuma S.
Periostin promotes malignant potential by induction of epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma..
Hepatol Commun, 25, 1099-1109, 2017

166. Dhami S, Kakourou A, Asamoah F, Agache I, Lau S, Jutel M, Muraro A, Roberts G, Akdis CA, Bonini M, Cavkaytar O, Flood B, Gajdanowicz P, Izuhara K, Kalayci Ö, Mosges R, Palomares O, Pfaar O, Smolinska S, Sokolowska M, Asaria M, Netuveli G, Zaman H, Akhlaq A, Sheikh A.
Allergen immunotherapy for allergic asthma: A systematic review and meta-analysis.
Allergy, 72, 1825-1848, 2017

165. Asamoah F, Kakourou A, Dhami S, Lau S, Agache I, Muraro A, Roberts G, Akdis C, Bonini M, Cavkaytar O, Flood B, Izuhara K, Jutel M, Kalayci Ö, Pfaar O, Sheikh A.
Allergen immunotherapy for allergic asthma: a systematic overview of systematic reviews
Clin Transl Allergy, 7, 25, 2017

164. Masaki K, Fukunaga K, Matsusaka M, Kabata H, Tanosaki T, Mochimaru T, Kamatani T, Ohtsuka K, Baba R, Ueda S, Suzuki Y, Sakamaki F, Oyamada Y, Inoue T, Oguma T, Sayama K, Koh H, Nakamura M, Umeda A, Kamei K, Izuhara K, Asano K, Betsuyaku T,
Characteristics of severe asthma with fungal sensitization
Ann Allergy Asthma Immunol, 119, 253-257, 2017

163. Izuhara K, Nunomura S, Nanri Y, Ogawa M, Ono J, Mitamura Y, Yoshihara T,
Periostin in inflammation and allergy
Cell Mol Life Sci, 74, 4293-4303, 2017

162. James A, Janson C, Malinovschi A, Holweg C, Alving K, Ono J, Ohta S, Ek A, Middelveld R, Dahlén B, Forsberg B, Izuhara K, Dahlén S-E,
Serum periostin relates to type-2 inflammation and lung function in asthma; data from the large population-based cohort Swedish GA(2)LEN
Allergy, 72, 1753-1760, 2017

161. Sunadome H, Matsumoto H, Petrova G, Kanemitsu,Y, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito Isao, Oguma T, Inoue H, Tajiri T, Iwata T, Izuhara Y, Ono J, Ohta S, Hirota T, Tamari M, Yokoyama T, Niimi A, Izuhara K, Mishima M,
IL4Rα and ADAM33 as genetic markers in asthma exacerbations and type-2 inflammatory endotype
Clin Exp Allergy, 47, 998-1006, 2017

160. Ishihara S, Shoda T, Ishimura N, Ohta S, Ono J, Azuma Y, Okimoto E, Izuhara K, Nomura I, Matsumoto K, Kinoshita Y,
Serum biomarkers for diagnosis of eosinophilic esophagitis and eosinophilic gastroenteritis
Intern Med, 56, 2819-2825, 2017

159. Nakama T, Yoshida S, Ishikawa K, Kubo Y, Kobayashi Y, Zhou Y, Nakao S, Hisatomi T, Ikeda Y, Takao K, Yoshikawa K, Matsuda A, Ono J, Ohta S, Izuhara K, Kudo A, Sonoda KH, Ishibashi T,
Therapeutic Effect of Novel Single-Stranded RNAi Agent Targeting Periostin in Eyes with Retinal Neovascularization
Mol Ther Nucleic Acids, 6, 279-289, 2017

158. Nagasaki T, Matsumoto H, Izuhara K, and the KiHAC Respiratory Medicine Group,
Utility of serum periostin in combination with exhaled nitric oxide in the management of asthma
Allergology International, 66, 404-410, 2017

157. Asano T, Kanemitsu Y, Takemura M, Yokota M, Fukumitsu K, Takeda N, Ichikawa H, Uemura T, Takakuwa O, Ohkubo H, Maeno K, Ito Y, Oguri T, Maki Y, Ono J, Ohta S, Nakamura Y, Izuhara K, Suzuki M, Niimi A,
Serum periostin as a biomarker for comorbid chronic rhinosinusitis in patients with asthma
Annals ATS, 14, 667-675, 2017

156. Ohta S, Okamoto M, Fujimoto K, Sakamoto N, Takahashi K, Yamamoto H, Kushima H, Ishii H, Akasaka K, Ono J, Kamei A, Azuma Y, Matsumoto H, Yamaguchi Y, Aihara M, Johkoh T, Kawaguchi A, Ichiki M, Sagara H, Kadota J, Hanaoka M, Hayashi S, Kohno S, Hoshino T, Izuhara K,
The usefulness of monomeric periostin as a biomarker for idiopathic pulmonary fibrosis
PLOS ONE, 12, e0174547, 2017

155. Komiya K, Ohta S, Arima K, Ogawa M, Suzuki S, Mitamura Y, Nunomura S, Nanri Y, Yoshihara T, Kagwaguchi A, Kadota J, Bruce K. Rubin, Izuhara K,
Clarithromycin attenuates IL-13?induced periostin production in human lung fibroblasts
Respir Res, 18, 37, 2017

154. Kimura H, Konno S, Nakamaru Y, Makita H, Taniguchi N, Shimizu K, Suzuki M, Ono J, Izuhara K, Nishimura M,
Sinus computed tomographic findings in adult smokers and nonsmokers with asthma. analysis of clinical indices and biomarkers
Annals ATS, 14, 332-341, 2017

153. Matsumoto H, Kanemitsu Y, Nagasaki T, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Izuhara Y, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Ono J, Ohta S, Hirota T, Kawaguchi T, Tamari M, Yokoyama T, Tabara Y, Matsuda F, IIzuhara K, Niimi A, Mishima M,
Staphylococcus aureus enterotoxin sensitization involvement and its association  with CysLTR1 variant in different asthma phenotypes
Annals of Allergy, Asthma & Immunology, 118, 197-203, 2017

152. Ishimori A, Harada N, Chiba A, Harada S, Matsuno K, Makino F, Ito J, Ohta S, Ono J, Atsuta R, Izuhara K, Takahashi K, Miyake S
Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma
Allergology International, 66, 302-309, 2017

151.Thuwajit C, Thuwajit P, Jamjantra P, Pairojkul C, Wongkham S, Bhudhisawasdi V, Ono J, Ohta S, Fujimoto K, Izuhara K
Clustering of intrahepatic cholangiocarcinoma patients based on serum periostin can predict its prognosis
Oncology Letters, 14, 623-634, 2017

150. Suzaki I, Kawano S, Komiya K, Tanabe T, Akaba T, Asano K, Suzaki H, Izuhara K, Rubin BK
IL-13 induces periostin production in airway epithelial cells, and inhibiting periostin attenuates IL-13-induced MUC5AC protein expression
Respirology, 22, 93-100, 2017

149. Sugiyama A, Kanno K, Nishimichi N, Ohta S, Ono J, Conway SJ, Izuhara K, Yokosaki Y, Tazuma S
Periostin promotes hepatic fibrosis in mice by modulating hepatic stellate cell activation via αv integrin interaction
Journal of Gastroenterology, 51, 1161–1174, 2016

148. Suzuki S, Ogawa M, Ohta S, Arima K, Nunomura S, Nanri Y, Mitamura Y, Yoshihara T, Nakamura Y, Yamauchi K, Chibana K, Ishii Y, Lee JJ, Aratani Y, Kakuta S, Kubo S, Iwakura Y, Yoshida H, Izuhara K
The potential for repositioning anti-thyroid agents as anti-asthma drugs
J Allergy Clin Immunol, 138, 1458-1461, 2016

147. Kim M, Yoon MK, Lee Y-S, Izuhara K, Ohta S, Ono J, Kim J-H, Ban GY, Ye Y-M, Park H-S
Clinical implication of the serum periostin level for differentiating phenotypes of NSAID hypersensitivity
Allergology International, 65, 492-494, 2016

146.Tajiri T, Matsumoto H, Gon Y, Ito R, Hashimoto S, Izuhara K, Suzukawa M, Ohta K, Ono J, Ito I, Oguma T, Inoue H, Iwata T, Nagasaki T, Kanemitsu T, Niimi A, Mishima M
Serum periostin and free IgE levels in the responsiveness to omalizumab in patients with severe asthma
Allergy, 71, 1472–1479, 2016

145. Inoue T, Akashi K, Watanabe M, Ikeda Y, Ashizuka S, Motoki T, Suzuki R, Sagara N, Yanagida N, Sato S, Ebisawa M, Ohta S, Ono J, Izuhara K, Katunuma T
Periostin as a biomarker for diagnosis of pediatric asthma
Pediatric Allergy and Immunology, 27, 521-526, 2016

144. Dhami S, Nurmatov U, Agache I, Lau S, Muraro A, Jutel M, Roberts G, Akdis C, Bonini M, Calderon M, Casale T, Cavkaytar O, Cox L, Demoly P, Flood B, Hamelmann E, Izuhara K, Kalayci Ö, Kleine-Tebbe J, Nieto A, Papadopoulos N, Pfaar O, Rosenwasser L, Ryan D, Schmidt-Weber C, Szefler S, Wahn U, van Wijk RG, Wilkinson J, Sheikh A
Allergen immunotherapy for allergic asthma: protocol for a systematic review
Clinical and Translational Allergy, 6, 5, 2016

143. Izuhara K, Ohta S, Ono S
Using periostin as a biomarker in the treatment of asthma
Allergy, Asthma and Immunology Research, 8, 491-498, 2016

142. Fujishima H, Okada N, Matsumoto K, Fukagawa K, Igarashi A, Matsuda A, Ono J, Ohta S, Mukai H, Yoshikawa M, Izuhara K
The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases
Journal of Allergy and Clinical Immunology, 138, 459-467, 2016

141. Hinks T, Brown T, Lau LCK, Rupani H, Barber C, Elliott S, Ward JA, Ono J, Ohta S, Izuhara K, Djukanovi? R, Kurukulaaratchy R, Chauhan A, Howarth PH
Multidimensional endotyping in severe asthma reveals inflammatory heterogeneity in MMPs and YKL-40
Journal of Allergy and Clinical Immunology, 138, 61-75, 2016

140. Bae Y, Izuhara K, Ohta S, Ono J, Hong GU, Ro JY, Park GH, Choi JH.
Periostin and Interleukin-13 Are Independently Related to Chronic Spontaneous Urticaria
Allergy, Asthma & Immunology Research, 8, 457-460, 2016

139. Watanabe Y, Yamaguchi Y, Komitsu N, Ohta S, Azuma Y, Izuhara K, Aihara M
Elevation of serum squamous cell carcinoma antigen 2 in patients with psoriasis: associations with disease severity and response to the treatment
British Journal of Dermatology, 174, 1327-1336, 2016

138. Izuhara K, Conway SJ, Moore BB, Matsumoto H, Holweg CTJ, Matthews JG, Arron JR
Roles of periostin in respiratory disorders
American Journal of Respiratory and Critical Care Medicine, 193, 949-956, 2016

137. James AJ, Reinius LE, Verhoek M, Gomes A, Kupczyk M, Hammar U, Ono J, Ohta S, Izuhara K, Bel E, Kere J, Söderhäll C, Dahlén B, Boot RG, Dahlén S
Increased YKL-40 and chitotriosidase in asthma and chronic obstructive pulmonary disease
American Journal of Respiratory and Critical Care Medicine, 193, 131-142, 2016

136. Tachibana T, Yoshida S, Kobayashi Y, Nakama T, Ishikawa K, Nakao S, Izuhara K, Kono T, Ishibashi T
Reduced vitreal concentration of periostin after vitrectomy in patients with proliferative diabetic retinopathy
Acta Ophthalmologica, 94, e81-e82, 2016

2016-↑

135. Yoshida S, Kobayashi Y, Nakama T, Zhou Y, Ishikawa K, Arita R, Nakao S, Miyazaki M, Sassa Y, Oshima Y, Izuhara K, Kono T, Ishibashi T
Increased expression of M-CSF and IL-13 in vitreous of patients with proliferative diabetic retinopathy: Implications for M2 macrophage-involving fibrovascular membrane formation
British Journal of Ophthalmology, 99, 629-634, 2015

134. Konradsen JR, Skantz E, Nordlund B, Lidegran M, James A, Ono J, Ohta S, Izuhara K, Dahlén S, Alving K, Hedlin G
Predictive values of proposed Th2 markers on asthma morbidity in children
Pediatric Allergy and Immunology, 26, 772-779, 2015

133. Chen C-Y, Lee J-B, Liu B, Ohta S, Wang P-Y, Kartashov A, Mugge L, Abonia JP, Barski A, Izuhara K, Rothenberg ME, Finkelman FD, Hogan SP, Wang Y-S
Induction of interleukin-9-producing mucosal mast cells promotes susceptibility to IgE-mediated experimental food allergy
Immunity, 43, 788-802, 2015

132. Izuhara K, Matsumoto H, Ohta S, Ono J, Arima K, Ogawa M
Recent developments regarding periostin in bronchial asthma
Allergology International, 64, S3-S10, 2015

131. Song JS, You JS, Jeong SI, Yang S, Hwang IT, Im YG, Baek HS, Kim HY, Izuhara K
Serum periostin levels correlate with airway hyperresponsiveness to methacholine and mannitol in children with asthma
Allergy, 70, 674-681, 2015

130. Fukuda K, Sugihara E, Ohta S, Izuhara K, Funakoshi T, Amagai M, Saya H
Periostin is a key niche component for wound metastasis of melanoma
PLOS One, 10, e0129704, 2015

129. Inoue Y, Izuhara K, Ohta S, Ono J, Shimojo N
No increase in the serum periostin level is detected in elementary school-age children with allergic diseases
Allergology International, 64, 289-290, 2015

128.
Nakamura Y, Nagashima H, Ohta S, Ono J, Yamauchi K, Izuhara K
Periostin in the bronchial lavage fluid of asthma patients
Allergology International, 64, 209-210, 2015

127. Kobayashi Y, Yoshida S, Nakama T, Zhou Y, Ishikawa K, Arita R, Nakao S, Miyazaki M, Sassa Y, Oshima Y, Izuhara K, Kono T, Ishibashi T
Overexpression of CD163 in vitreous and fibrovascular membranes of patients with proliferative diabetic retinopathy: possible involvement of periostin
British Journal of Ophthalmology, 99, 451-456, 2015

126. Matsusaka M, Kabata H, Fukunaga K, Suzuki Y, Masaki K, Mochimaru T, Sakamaki F, Oyamada Y, Inoue T, Oguma T, Sayama K, Koh H, Nakamura M, Umeda A, Ono J, Ohta S, Izuhara K, Asano K, Betsuyaku T
Phenotype of asthma related with high serum periostin levels
Allergology International, 64, 175-180, 2015

125. Tajiri M, Okamoto M, Fujimoto K, Johkoh T, Ono J, Kaieda S, Azuma K, Kawayama T, Ohta S, Izuhara K, Hoshino T
Serum level of periostin can predict long-term outcome of idiopathic pulmonary fibrosis
Respiratory Investigation, 53, 73-81, 2015

124. Arima K, Ohta S, Takagi A, Shiraishi H, Masuoka M, Ontsuka K, Suto H, Suzuki S, Yamamoto K, Ogawa M, Simmons O, Yamaguchi Y, Toda S, Aihara M, Conway SJ, Ikeda S, Izuhara K
Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis
Allergology International, 64, 41-48, 2015

123. Nagasaki T, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Horiguchi T, Kita H, Tomii K, Fujimura M, Yokoyama A, Nakano Y, Hozawa S, Ito I, Oguma T, Izuhara Y, Tajiri T, Iwata T, Ono J, Ohta S, Yokoyama T, Niimi A, Mishima M
Using exhaled nitric oxide and serum periostin as+ a composite marker to identify severe/steroid-insensitive asthma
American Journal of Respiratory and Critical Care Medicine, 190, 1449-1452, 2014

122. Kim MA, Izuhara K, Ohta S, Ono J, Yoon MK, Ban GY, Yoo HS, Shin YS, Ye YM, Nahm DH, Park HS
Association of serum periostin with aspirin-exacerbated respiratory disease
Annals of Allergy, Asthma & Immunology, 113, 314-320, 2014

121. Kanemitsu Y, Ito I, Niimi A, Izuhara K, Ohta S, Ono J, Iwata T, Matsumoto H, Mishima M
Osteopontin and periostin associate with a 20-year decline of pulmonary function in asthmatics
American Journal of Respiratory and Critical Care Medicine, 190, 472-474, 2014

120. Lianidou E, Ahmad-Nejad P, Izuhara K, Cremonesi L, Schröder M, Richter K, Neumaier M
Advancing the education in molecular diagnostics: The IFCC Initiative "Clinical Molecular Biology Curriculum" (C-CMBC); A ten-years experience
Clinica Chimica Acta, 436, 5-8, 2014

119. Ohta N, Ishida A, Kurakami K, Kakehata S, Ono J, Okubo K, Ikeda H, Izuhara K
The expressions and roles of periostin in otolaryngological diseases
Allergology International, 63, 171-180, 2014

118. Kotobuki Y, Tanemura A, Serada S, Yang L, Nomura S, Kudo A, Izuhara K, Murota H, Fujimoto M, Katayama I, Naka T
Periostin accelerates human malignant melanoma progression by modificating the melanoma microenvironment
Pigment Cell & Melanoma Research, 27, 630-639, 2014

117. Kou K, Okawa T, Yamaguchi Y, Ono J, Inoue Y, Kohno M, Matsukura S, Kambara T, Ohta S, Izuhara K, Aihara M
Periostin levels correlate disease severity and chronicity in patients with atopic dermatitis
British Journal of Dermatology, 171, 283-291, 2014

116. Izuhara Y, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Ono J, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M
GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids
Allergy, 69, 668-673, 2014

115. Nagasaki T, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Kita H, Horiguchi T, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Izuhara Y, Ono J, Ohta S, Yokoyama T, Niimi A, Mishima M
Integrating longitudinal information on pulmonary function and inflammation using asthma phenotypes
Journal of Allergy and Clinical Immunology, 133, 1474-1477, 2014

114. Ando A, Xiao W, Gao P, Namiranian S, Matsumoto K, Tomimori1 Y, Hong H, Yamashita H, Kimura M, Kashiwakura J, Hata TR, Izuhara K, Gurish MF, Roers A, Rafaels NF, Barnes KC, Jamora C, Kawakami Y, Kawakami T
Critical role for mast-cell Stat5 activity in skin inflammation
Cell Reports, 6, 366-376, 2014

113. Izuhara K, Arima K, Ohta S, Suzuki S, Inamitsu M, Yamamoto K
Periostin in allergic inflammation
Allergology International, 63, 143-151, 2014

112. Conway SJ, Izuhara K, Kudo Y, Litvin J, Markwald R, Ouyang G, Arron JR, Holweg CT, Kudo A
The role of periostin in tissue remodeling across health and disease.
Cellular and Molecular Life Sciences, 71, 1279-1288, 2014

111. Taniguchi K, Arima K, Masuoka M, Ohta S, Shiraishi H, Ontsuka K, Suzuki S, Inamitsu M, Yamamoto K, Simmons O, Toda S, Conway SJ, Hamasaki Y, IzuharaK
Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1a/IL-6 loop
Journal of Investigative Dermatology, 134, 1295-1304, 2014

110. Ishikawa K, Yoshida S, Nakao S, Nakama T, Kita T, Asato R, Sassa Y, Arita R, Miyazaki M, Enaida H, Oshima Y, Murakami N, Niiro H, Ono J, Matsuda A, Goto Y, Akashi K, Izuhara K, Kudo A, Kono T, Hafezi-Moghadam A, Ishibashi T
Periostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy
FASEB Journal, 28, 131-142, 2014

109. Ohta N, Kurakami K, Ishida A, Furukawa T, Suzuki Y, Aoyagi M, Matsubara A, Izuhara K, Kakehata S
Roles of TGF-beta and periostin in fibrosclerosis in patients with IgG4-related diseases
Acta Oto-Laryngologica, 133, 1322-1327, 2013

108. Ohta N, Watanabe T, Ito T, Kubota T, Suzuki Y, Ishida A, Kakehata S, Aoyagi M, Matsubara A, Izuhara K
Clinical and pathological characteristics of organized hematoma
International Journal of Otolaryngology, 2013, 539642, 2013

107. Kato G, Takahashi K, Izuhara K, Komiya K, Kimura S, Hayashi S
Markers that can reflect asthmatic activity before and after reduction of inhaled corticosteroids: A pilot study
Biomarker Insights, 8, 97-105, 2013

106. Kanemitsu Y, Matsumoto H, Izuhara K, Tohda Y, Kita H, Horiguchi T, Kuwahara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Izuhara Y, Ono J, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M
Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids
Journal of Allergy and Clinical Immunology, 132, 305-312, 2013

105. Tajiri T, Matsumoto H, Hiraumi H, Ikeda H, Morita K, Izuhara K, Ono J, Ohta S, Ito I, Oguma T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Kanemitsu Y, Ito J, Niimi A, Mishima M
Efficacy of omalizumab in eosinophilic chronic rhinosinusitis patients with asthma
Annals of Allergy, Asthma & Immunology, 110, 387-388, 2013

104. Yamaguchi Y, Ono J, Masuoka M, Ohta S, Izuhara K, Ikezawa Z, Aihara M, Takahashi K:
Serum periostin levels correlate with the progressive skin sclerosis in patients with systemic sclerosis
British Journal of Dermatology, 168, 717-725, 2013

103. Ishida I, Ohta N, Suzuki, Y, Kakehata S, Okubo K, Ikeda H, Shiraishi H, Izuhara K: Expression of pendrin and periostin in allergic rhinitis and chronic rhinosinusitis
Allergology International, 61, 589-595, 2012

102. Shiraishi H, Masuoka M, Ohta S, Suzuki S, Arima K, Taniguchi K, Aoki S, Toda S, Yoshimoto T, Inagaki N, Conway SJ, Narisawa Y, Izuhara K:
Periostin contributes to the pathogenesis of atopic dermatitis by inducing TSLP production from keratinocytes.
Allergology International, 61, 563-572, 2012

101. Nishizawa H, Matsubara A, Nakagawa T, Ohta N, Izuhara K, Shinkawa H:
The role of periostin in eosinophilic otitis media
Acta Oto-Laryngologica, 132, 838-844, 2012

100. Masuoka M, Shiraishi H, Ohta S, Suzuki S, Arima K, Aoki S, Toda S, Inagaki N,   Kurihara Y, Hayashida S, Takeuchi S, Koike K, Ono J, Noshiro H, Furue M, Conway   SJ, Narisawa Y, Izuhara K:
Periostin promotes chronic allergic inflammation in response to Th2 cytokines
Journal of Clinical Investigation, 122, 2590-2600, 2012

99. Ohta N, Kurakami K, Ishida A, Furukawa T, Saito F, Kakehata S, Izuhara K:
Clinical and pathological characteristics of IgG4-related sclerosing sialadenitis
Laryngoscope, 122, 572-577, 2012

98. Ontsuka K, Kotobuki Y, Shiraishi H, Serada S, Ohta S, Tanemura A, Yang L, Fujimoto M, Arima K, Suzuki S, Murota H, Toda S, Kudo A, Conway SJ, Narisawa Y, Katayama I, Izuhara K, Naka T:
Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts
Experimental Dermatology, 21, 331-336, 2012

97. Uchida M, Shiraishi H, Ohta S, Arima K, Taniguchi K, Suzuki S, Okamoto M, Ahlfeld SK, Ohshima K, Kato S, Toda S, Sagara H, Aizawa H, Hoshino T, Conway SJ, Hayashi S, Izuhara K:
Periostin, a matricellular protein, plays a role in the induction of chemokines in pulmonary fibrosis
American Journal of Respiratory Cell and Molecular Biology, 46, 677-686, 2012

96. Ohta S, Shibata R, Nakao Y, Azuma Y, Taniguchi K, Arima K, Suzuki S, Shiraishi H, Iwasaka T, Izuhara K:
The usefulness of combined measurements of squamous cell carcinoma antigens 1 and 2 in diagnosing atopic dermatitis
Annals of Clinical Biochemistry, 49, 277-284, 2012

95. Nofziger C, Dossena S, Suzuki S, Izuhara K, Paulmichl M:
Pendrin function in airway epithelia
Cellular Physiology and Biochemistry, 28, 571-578, 2011

94. Taniguchi K, Yamamoto S, Aoki S, Izuhara K, Hamasaki Y:
Epigen is induced during the interleukin-13-stimulated cell proliferation in murine primary airway epithelial cells
Experimental Lung Research, 37, 461-470, 2011

93. Yoshida S, Ishikawa K, Asato R, Arima M, Sassa Y, Yoshida A, Yoshikawa H, Narukawa K, Obika S, Ono J, Ohta S, Izuhara K, Kono T, Ishibashi T:
Increased expression of periostin in vitreous and fibrovascular membranes obtained from patients with proliferative diabetic retinopathy
Investigative Ophthalmology & Visual Science, 52: 5670-5678, 2011

92. Okamoto M, Hoshino T, Kitasato Y, Sakazaki Y, Kawayama T, Fujimoto K, Ohshima K, Shiraishi H, Uchida M, Ono J, Ohta S, Kato S, Izuhara K, Aizawa H:
Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias
European Respiratory Journal, 37: 1119-1127, 2011

91.Fujimoto K, Kawaguchi T, Nakashima O, Ono J, Ohta S, Kawaguchi A, Tonan T, Ohshima K, Yano H, Hayabuchi N, Izuhara K, Sata M:
Periostin, a matrix protein, has potential as a novel serodiagnostic marker for cholangiocarcinoma
Oncology Reports, 25, 1211-1216, 2011

90. Ohtsuka Y, Kanaji T, Nishi M, Sakai N, Sato T, Aoki S, Wakayama K, Nakazato S, Hisano S, Sado Y, Kawachi H, Izuhara K, Hamasaki Y:
A notable case report of May-Hegglin anomaly with immune complex-related nephropathy: a genetic and histological analysis
Clinical Nephrology, 75, 255 - 262, 2011

2011-↑

89. Matsushita M, Ohta S, Shiraishi H, Suzuki S, Arima K, Toda S, Tanaka H, Nagai H, Kimoto M, Inokuchi A, Izuhara K:
Endotoxin tolerance attenuates airway allergic inflammation in model mice by suppression of the T-cell stimulatory effect of dendritic cells
International Immunology, 22, 739-747, 2010

88. Suzuki K, Inokuchi A, Miyazaki J, Kuratomi Y, Izuhara K:
Relationship between squamous cell carcinoma-related antigen and the clinical severity in allergic rhinitis patients caused by D. farinae and Japanese cedar pollen
Annals of Otology, Rhinology & Laryngology, 119, 22-26, 2010

87. Ito T, Suzuki S, Kanaji S, Shiraishi H, Ohta S, Arima K, Tanaka G, Tamada T, Honjo E, Garcia KC, Kuroki R, Izuhara K:
Distinct structural requirements for IL-4 and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness.
Journal of Biological Chemistry, 284, 24289-24296, 2009

86. Izuhara K, Ohta S, Shiraishi H, Suzuki S, Taniguchi K, Toda S, Tanabe T, Yasuo M, Kubo K, Hoshino T, Aizawa H:
The mechanism of mucus production in bronchial asthma.
Current Medicinal Chemistry, 16, 2867-2875, 2009

85. Kanaji S, Kanaji T, Honda M, Nakazato S, Wakayama K, Tabata Y, Shibata S, Gondo H, Nakamura I, Node K, Miura M, Miyahara M, Okamura T, Nagumo F, Ohta S, Izuhara K: Identification of four novel mutations in F5 associated with congenital factor V deficiency.
International Journal of Hematology, 89, 71-75, 2009

84. Ohta SCAzuma YCShiraishi HCNoguchi YCIzuhara K:
Establishment of the diagnostic system for allergic diseases aiming the
personalized medicine -Establishment of a novel ELISA system for SCCA-
Rinsho Byori, 56, 980-985, 2008 (Japanese)

83. 86 Sonoda E, Aoki S, Uchihashi K, Soejima H, Kanaji S, Izuhara K, Satoh S, Fujitani N, Sugihara H, Toda S: A new organotypic culture of adipose tissue fragments maintains viable mature adipocytes for a long term, together with development of immature adipocytes and mesenchymal stem cell-like cells. Endocrinology, 149, 4794-4798, 2008

82. Izuhara K, Ohta S, Kanaji S, Shiraishi H, Arima K:
Recent progress in understanding the diversity of the human ov-serpin/clade B serpin family.
Cellular and Molecular Life Sciences, 65, 2541-2553, 2008

81.Oku E, Kanaji T, Takata Y, Oshima K, Seki R, Morishige S, Imamura R, Ohtsubo K, Hashiguchi M, Osaki K, Yakushiji K, Yoshimoto K, Ogata H, Hamada H, Izuhara K, Sata M, Okamura T: Periostin and bone marrow fibrosis
International Journal of Hematology, 88, 57-63, 2008

80. Honjo E, Shoyama Y, Tamada T, Shigematsu H, Hatanaka T, Kanaji S, Arima K, Ito Y, Izuhara K, Kuroki R. Expression of the extracellular region of the human interleukin-4 receptor ? chain and interleukin-13 receptor ?1 chain by a silkworm-baculovirus system.
Protein Expression and Purification, 60, 25-30, 2008

79. Nakao I, Kanaji S, Ohta S, Matsushita H, Arima K, Yuyama N, Yamaya M, Nakayama K, Kubo H, Watanabe M, Sagara H, Sugiyama K, Tanaka H, Toda S, Hayashi H, Inoue H, Hoshino T, Nakajima A, Inoue M, Suzuki K, Aizawa H, Okinami S, Nagai H, Hasegawa M, Fukuda T, Green ED, Izuhara K: Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease.
Journal of Immunology
, 180, 6262-6269, 2008

78. Izuhara K, Kanaji S, Arima K, Ohta S, Shiraishi H: Involvement of cysteine protease inhibitors in the defense mechanism against parasites
Medicinal Chemistry, 4, 322-327, 2008

77. Kanaji S, Kanaji T, Migita M, Kunishima S, Kunicki TJ, Okamura T, Izuhara K: Characterization of a patient with atypical amegakaryocytic thrombocytopenia. European Journal of Haematology, 80, 361-364, 2008

76. Ohkuri T, Takeda C, Yoshida Y, Izuhara K, Imoto T, Ueda T: Expression of human IL-13 receptor ?2 extracellular domain in Pichia pastoris. Protein Expression and Purification, 56, 48-53, 2007

75. Kanaji S, Tanaka Y, Sakata Y, Takeshita K, Arima K, Ohta S, Hansell EJ, Caffrey C, Mottram JC, Lowther J, Donnelly S, Stack C, Kadowaki T, Yamamoto K, McKerrow JH, Dalton JP, Coombs GH, Izuhara K:
Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases
FEBS Letters, 581, 4260-4264, 2007

74. Hayashi N, Yoshimoto T, Izuhara K, Matsui K, Tanaka T, Nakanishi K:
T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-g and IL-13 production     
Proceedings of the National Academy of Sciences of the United States of America, 104, 14765-14770, 2007

73. Andrews A-L, Buccheri F, Arima K, Izuhara K, Holgate ST, Davies DE Holloway JW:
Effect of IL-13Ra2 Receptor levels on the biological activity of IL-13 variant R110Q
Journal of Allergy and Clinical Immunology, 120, 91-97, 2007

72. Yoshida Y, Ohkuri T, Takeda C, Kuroki R, Izuhara K, Imoto T, Ueda T:
Analysis of internal motions of interleukin 13 variant associated with severe bronchial asthma using 15N NMR relaxation
Biochemical and Biophysical Research Communications, 358, 292-297, 2007

71. Izuhara K, Arima K, Kanaji S, Kanaji T, Ohta S:
IL-13 and its signal pathway: promising targets in the development of a therapeutic agent for bronchial asthma
Current Signal Transduction Therapy, 2, 31-40, 2007

70. Izuhara K, Saito H:
Microarray-based identification of novel biomarkers in asthma
Allergology International, 4: 361-367, 2006

69. Izuhara K, Arima K, Kanaji S, Ohta S, Kanaji T:
IL-13: A promising therapeutic target for bronchial asthma
Current Medicinal Chemistry, 13, 2291-2298, 2006

68. Takayama G, Arima K, Kanaji T, Toda S, Tanaka H, Shoji S, McKenzie AN J, Nagai H, Hotokebuchi T, Izuhara K:
Periostin: A novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals
Journal of Allergy and Clinical Immunology, 118: 98-104, 2006

67. Koike E, Toda S, Yokoi F, Izuhara K, Koike N, Itoh K, Miyazaki K, Sugihara H:
Expression of new human inorganic pyrophosphatase in thyroid diseases: Its intimate association with hyperthyroidism
Biochemical and Biophysical Research Communications, 341, 691-696, 2006

66. Goda C, Kanaji T, Kanaji S, Tanaka G, Arima K, Ohno S, Izuhara K:
Involvement of IL-32 in activation-induced cell death in T cells
International Immunology, 18, 233-240, 2006

2006-↑

65. Terada N, Kobayashi T, Suzuki T, Yamazaki K, Izuhara K, Konno A:
Aiming towards effective preventive medicine against Japanese cedar pollinosis: epidermiology, patient investigation and integrated research including genotype analyses
Clinical & Experimental Allergy Reviews, 5, 50-54, 2005

64. Mitsuishi K, Nakamura T, Sakata Y, Yuyama N, Arima K, Sugita Y, Suto H, Izuhara K, Ogawa H:
The squamous cell carcinoma antigens as relevant biomarkers of atopic dermatitis
Clinical & Experimental Allergy, 35, 1327-1333, 2005

63. Matsuda A, Hirota T, Akahoshi M, Shimizu M, Tamari M, Miyatake A, Takahashi A, Nakashima K, Takahashi N, Obara K, Yuyama N, Doi S, Kamogawa Y, Enomoto T, Ohshima K, Tsunoda T, Miyatake S, Fujita K, Kusakabe M, Izuhara K, Nakamura Y, Hopkin J, Shirakawa T:
Coding SNP in tenascin-C Fn-III-D domain associates with adult asthma
Human Molecular Genetics, 14, 2779-2786, 2005

62. Tanaka G, Kanaji S, Hirano A, Arima K, Shinagawa A, Goda C, Yasunaga S, Ikizawa K, Yanagihara Y, Kubo M, Kuriyama-Fujii Y, Sugita Y, Inokuchi A, Izuhara K:
Induction and Activation of the Aryl Hydrocarbon Receptor by Interleukin-4 in B cells
International Immunology, 17, 797-805, 2005

61. Kanaji S, Kanaji T, Jacquelin B, Chang M, Nugent DJ, Komatsu N, Moroi M, Izuhara K, Kunicki TJ:
Thrombopoietin initiates demethylation-based transcription of GP6 during megakaryocyte differentiation.
Blood, 105, 3888-3892, 2005

60. Arima K, Sato K, Tanaka G, Kanaji S, Terada T, Honjo E, Kuroki R, Matsuo Y, Izuhara K:
Characterization of the interaction between interleukin-13 and interleukin-13 receptors
Journal of Biological Chemistry, 280, 24915-24922, 2005

59. Arima K and Izuhara K:
The IL-13/IL-13 receptor interaction, an emerging therapeutic target in allergic diseases
Allergology International, 54, 229-233, 2005

58. Izuhara K, Arima K, Masumoto K, Kanaji S, Kanaji T:
IL-4 and IL-13: Their pathological roles in allergic diseases and their potential in developing new therapies-Update
Medicinal Chemistry Reviews- Online, 2, 149-152, 2005

57. Nishi N, Miyazaki M, Tsuji K, Hitomi T, Muro E, Zaitsu M, Yamamoto S, Inada S, Kobayashi I, Ichimaru T, Izuhara K, Nagumo F, Yuyama N, and Hamasaki Y:
Squamous cell carcinoma-related antigen (SCCA) in children with acute asthma
Annals of Allergy, Asthma & Immunology, 94, 391-397, 2005

56. Takai T, Kato T, Sakata Y, Yasueda H, Izuhara K, Okumura K, and Ogawa H
Recombinant Der p 1 and Der f 1 exhibit cysteine protease activity but not serine protease activity
Biochemical and Biophysical Research Communications, 328, 944-952, 2005

55. Izuhara K, Arima K, Yuyama N, Sakata Y, Masumoto K:
Application of functional genomics to bronchial asthma
Current Pharmacogenomics, 2:351-356, 2004

54. Kanaji T, Russell S, Cunningham J, Izuhara K, Fox JE, and Ware J:
Megakaryocyte proliferation and ploidy regulated by the cytoplasmic tail of glycoprotein Iba
Blood, 104:3161-3168, 2004

53. Sakata Y, Arima K, Takeshita K, Takai T, Aoki S, Ogawa H, Sugihara H, Fujimoto K, Izuhara K:
Characterization of novel squamous cell carcinoma antigen-related molecules in mice
Biochemical and Biophysical Research Communications, 324: 1340-1345, 2004

52. Kuzuya Y, Adachi T, Hara H, Anan A, Izuhara K, Nagai H: 
Induction of drug-metabolizing enzymes and transporters in human bronchial epithelial cells by beclomethasone dipropionate.
IUBMB Life, 56: 355-359, 2004

51. Seki N, Suzuki W, Miyazaki M, Seki Y, Hayashi K, Arima K, Izuhara K, Brombacher F, Kubo M:
IL-4-induced GATA-3 expression is a time-restricted instruction switch for Th2 cell differentiation
Journal of Immunology, 172: 6158-6166, 2004

50. Izuhara K, Arima K:
Signal transduction of IL-13 and its role in the pathogenesis of bronchial asthma
Drug News & Perspectives, 17: 91-98, 2004

49. Sakata Y, Arima K, Takai T, Sakura W, Masumoto K, Yuyama N , Suminami Y, Kishi F, Yamashita T, Kato T, Ogawa H, Fujimoto K, Matsuo Y, Sugita Y, Izuhara K:
The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1
Journal of Biological Chemistry, 279: 5081-5087, 2004

48. Masumoto K, Sakata Y, Arima K, Nakao I, Izuhara K:
Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1
Journal of Biological Chemistry, 278: 45296-45304, 2003

47. Yasunaga S, Yuyama N, Arima K, Tanaka H, Toda S, Maeda M, Matsui  K, Goda C, Yang Q, Sugita Y, Nagai H, Izuhara K:
The negative-feedback regulation of the IL-13 signal by the IL-13 receptor a2 chain in bronchial epithelial cells
Cytokine, 24: 293-303, 2003

46. Wongpiyabovorn J, Suto H, Ushio H, Izuhara K, Mitsuishi K, Ikeda S, Nakao A, Okumura K, Ogawa H:
Up-regulation of interleukin-13 receptor a1 on human keratinocytes in the skin of psoriasis and atopic dermatitis
Journal of Dermatological Science, 33: 31-40, 2003

45. Izuhara K:
The Role of interleukin-4 and interleukin-13 in the non-immunologic aspects of asthma pathogenesis
Clinical Chemistry and Laboratory Medicine, 41: 860-864, 2003

44. Yokoi F, Hiraishi H, Izuhara K:
Molecular cloning of a cDNA for the human phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Journal of Biochemistry, 133: 607-614, 2003

43. Izuhara K, Arima K, Yasunaga S, Yokoi F, Sakata Y, Tanaka T, Yang Q:
The importance of interleukin-13 in the pathogenesis of bronchial asthma
Recent Research Developments of Biochemistry, 3: 33-40, 2002

42. Yuyama N, Davies DE, Akaiwa M, Matsui K, Hamasaki Y, Suminami Y, Lu Yoshida N, Maeda M, Pandit A, Lordan JL, Kamogawa Y, Arima K, Nagumo F, Sugimachi M, Berger A, Richards I, Roberds SL, Yamashita T, Kishi F, Kato H, Arai K, Ohshima K, Tadano J, Hamasaki N, Miyatake S, Sugita Y, Holgate ST, Izuhara K:
Analysis of novel disease-related genes in bronchial asthma
Cytokine, 19: 287-296, 2002

41. Matsui K, Yuyama N, Akaiwa M, Yoshida NL, Maeda M, Sugita Y, Izuhara K:
Identification of an alternative splicing variant of cathepsin C/ dipeptidyl-peptidase I
Gene, 293: 1-7, 2002

40. Izuhara K, Arima K, Yasunaga S:
IL-4 and IL-13: Their pathological roles in allergic diseases and their potential in developing new therapies
Inflammation & Allergy-Drug Targets (formerly Current Drug Targets-Inflammation & Allergy, 1: 263-269, 2002

39. Arima K, Umeshita-Suyama R, Sakata Y, Akaiwa M, Mao X-Q, Enomoto T, Dake Y, Shimazu S, Yamashita T, Sugawara N, Brodeur S, Geha R, Puri RK, Sayegh MH, Adra CN, Hamasaki N, Hopkin JM, Shirakawa T, Izuhara K:
Upregulation of IL-13 concentration in vivo by the IL-13 variant associated with bronchial asthma
Journal of Allergy and Clinical Immunology, 109: 980-987, 2002

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38. Ikizawa K, Kajiwara K, Izuhara K, Yanagihara Y:
PKCd and z mediate IL-4/IL-13-induced germline e transcription in human B cells: a putative regulation via PU.1 phosphorylation
Biochemical and Biophysical Research Communications, 288: 34-41, 2001

37. Ohshima K, Akaiwa M, Umeshita R, Suzumiya J, Izuhara K, Kikuchi M:
Interleukin-13 and interleukin-13 receptor in Hodgkin's disease: possible autocrine mechanism and involvement in fibrosis
Histopathology, 38: 368-375, 2001

36. Akaiwa M, Yu B, Umeshita R, Terada N, Suto H, Koga T, Arima K, Matsushita S, Saito H, Ogawa H, Furue M, Hamasaki N, Ohshima K, Izuhara K:
Localization of human interleukin-13 receptor in non-hematopoietic cells
Cytokine, 13: 75-84, 2001

35. Izuhara K, Yanagihara Y, Hamasaki N, Shirakawa T, Hopkin, JM:
Atopy and the human Interleukin-4 Receptor a Chain
Journal of Allergy and Clinical Immunology, 106, S65-S71, 2000

34. Umeshita-Suyama, R., Sugimoto, R., Akaiwa, M., Arima, K., Yu, B., Wada, M., Kuwano, M., Nakajima, K., Hamasaki, N., and Izuhara, K.
Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation. International Immunology 12: 1499-1509 (2000).

33. Izuhara K, Umeshita-Suyama R, Akaiwa M, Shirakawa T, Deichmann KA, Arima K, Hamasaki N, Hopkin JM:
Recent advances in understanding how interleukin-13 signals are involved in the pathogenesis of bronchial asthma
Archivum Immunologiae et Therapiae Experimentalis, 48: 505-512, 2000

32. Takabayashi A, Ihara K, Sasaki Y, Suzuki Y, Nishima S, Izuhara K, Hamasaki N, Hara T:
Positive association with a polymorphism of interleukin-4 receptor a gene but not with that of interleukin-4 promoter or Fce receptor 1 b gene
Experimental and Clinical Immunogenetics, 17: 63-70, 2000

31. Arinobu Y, Sugimoto R, Akaiwa M, Arima K, Otsuka T, Hamasaki N, Izuhara K:
Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells
Biochemical and Biophysical Research Communications, 277: 317-324, 2000

30. Gao P-S, Mao X-Q, Roberts MH, Arinobu Y, Akaiwa M, Enomoto T, Dake Y, Kawai M, Sasaki S, Hamasaki N, Izuhara K, Shirakawa T, Hopkin JM:
Variants of STAT6 (signal transducer and activator of transcription 6) in atopic asthma
Journal of Medical Genetics, 37: 380-382, 2000      

29. Kojima M, Morisaki T, Izuhara K, Uchiyama A, Matsunari M, Katano M, Tanaka M:
Lipopolysaccharide increases cyclo-oxygenase-2 production in a colon carcinoma cell line through nuclear factor-kB activation
Oncogene, 19: 1225-1231, 2000

28. Heinzmann A, Mao X-Q, Akaiwa M, Kreomer RT, Gao P-S, Ohshima K, Umeshita R, Abe Y, Braun S, Yamashita T, Roberts MH, Sugimoto R, Arima K, Arinobu Y, Yu B, Kruse S, Enomoto T, Dake Y, Kawai M, Shimazu S, Sasaki S, Adra CN, Kitaichi M, Inoue H, Yamauchi K, Tomichi N, Kurimoto F, Hamasaki N, Hopkin JM, Izuhara K, Shirakawa T, Deichmann KA:
Genetic variants of IL-13 signalling and human asthma and atopy
Human Molecular Genetics, 9: 549-559, 2000

27. Shirakawa T, Deichman KA, Izuhara K, Mao X-Q, Adra CN, Hopkin JM:
Atopy and asthma: genetic variants of IL-4 and IL-13 signalling
Trends in Immunology (formerly Immunology Today), 21: 60-64, 2000

26. Nemoto Y, Otsuka T, Niiro K, Izuhara K, Yamaoka H, Nakashima H, Niho Y:
Differential effects of interleukin-4 and interleukin-10 on nitric oxide production by murine macrophages
Inflammation Research, 48: 643-650, 1999

25. Izuhara K, Shirakawa T, Adra CN, Hamasaki N, Hopkin JM:
Emerging therapeutic targets in allergy: IL-4Ra and Stat6
Emerging Therapeutic Targets, 3: 381-389, 1999

24. Yamaoka K, OtsukaT, Niiro N, Nakashima H, Tanaka Y, Nagano S, Ogami E, Niho Y, Hamasaki N, Izuhara K:
Selective DNA-binding activity of interleukin-10-stimulated STAT molecules in human monocytes
Journal of Interferon & Cytokine Research, 19: 679-685, 1999

23. Akaiwa M, Yae Y, Sugimoto R, Suzuki SO, Iwaki T, Izuhara K, Hamasaki N:
Hakata Antigen, a new member of the Ficolin/Opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile
Journal of Histochemistry & Cytochemistry, 47: 777-785, 1999

22. Izuhara K, Arinobu Y, Sumimoto H, Nunoi N, Takeya R, Higuchi K, Takeshige K, Hamasaki N, Harada N:
Association of the interleukin-4 receptor a chain with p47phox, an activator of the phagocyte NADPH oxidase in B cells
Molecular Immunology, 36: 45-52, 1999

21. Arinobu Y, Atamas SP, Otsuka T, Niiro H, Yamaoka K, Mitsuyasu H, Niho Y, Hamasaki N, White B, Izuhara K:
Antagonistic effects of an alternative splice variant of human IL-4, IL-4d2, on IL-4 activities in human monocytes and B cells
Cellular Immunology, 191: 161-167, 1999

20. Mitsuyasu H, Yanagihara Y, Mao X-Q, Gao P-S, Arinobu Y, Ihara K, Takabayashi A, Hara T, Enomoto T, Sasaki S, Kawai M, Hamasaki N, Shirakawa T, Hopkin JM, Izuhara K:
Dominant effect of Ile50Val variant of the human interleukin-4 receptor a chain in IgE synthesis
Journal of Immunology, 162: 1227-1231, 1999

19. Kanai N, Yanai F, Hirose S, Nibu K, Izuhara K, Tani T, Kubota T, Mitsudome A:
A "G" to "A" transition at the last nucleotide mutation of exon 6 of the gc gene (868G→A) may result in either a splice or missense mutation in patients with X-linked severe combined immunodeficiency
Human Genetics, 104: 36-42, 1999

18. Izuhara K, Shirakawa T:
The Signal transduction via the interleukin-4 receptor and its correlation with atopy
International Journal of Molecular Medicine, 3: 3-10, 1999

17. Niiro H, Otsuka T, Ogami E, Yamaoka K, Nagano S, Akahoshi M, Nakashima H, Arinobu Y, Izuhara K, Niho Y:
MAP kinase pathways as a route for regulatory mechanisms of IL-10 and IL-4 which inhibit COX-2 expression in human monocytes                
Biochemical and Biophysical Research Communications, 250: 200-205, 1998

16. Sugimoto R, Yae Y, Akaiwa M, Kitajima S, Shibata Y, Sato H, Hirata J, Okochi K, Izuhara K, Hamasaki N:
Cloning and characterization of Hakata Antigen, a member of the Ficolin/Opsonin p35 lectin family
Journal of Biological Chemistry, 273: 20721-20727, 1998

15. Harada N, Higuchi K, Wakao H, Hamasaki N, Izuhara K:
Identification of the critical portions of the human IL-4 receptor a chain of activation of STAT6
Biochemical and Biophysical Research Communications, 246: 675-680, 1998

14. Mitsuyasu M, Izuhara K, Mao X-Q, Arinobu Y, Enomoto T, Kawai M, Sasaki S, Gao P-S, Dake Y, Hamasaki N, Shirakawa T, Hopkin JM:        
Ile50Val variant of IL4Ra upregulates IgE synthesis and associates with atopic asthma
Nature Genetics, 19: 119-120, 1998

13. Murakami Y, Nakano S, Niho Y, Hamasaki N, Izuhara K:
Constitutive activation of Jak-2 and Tyk-2 in a v-Src-transformed human gallbladder adenocarcinoma cell line
Journal of Cellular Physiology, 175: 220-228, 1998

12. Yamaoka K, Otsuka T, Niiro H, Arinobu Y, Niho Y, Hamasaki N, Izuhara K:
Activation of STAT5 by lipopolysaccharide through granulocyte-macrophage colony-stimulating factor production in human monocytes
Journal of Immunology, 160: 838-845, 1998


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11. Niiro H, Otsuka T, Izuhara K, Yamaoka K, Ohshima K, Tanabe T, Hara S, Nemoto Y, Tanaka Y, Nakashima H, Niho Y:
Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils
Blood, 89:1621-1628, 1997

10. Izuhara K, Heike T, Otsuka T, Yamaoka Y, Imamura T, Mayumi M, Niho Y,  
Harada N:
Signal transduction pathway of interleukin-4 and interleukin-13 in human B cells derived from X-linked severe combined immunodeficiency patients 
Journal of Biological Chemistry, 271:619-622, 1996                           

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9. Izuhara K, Harada N:
Interleukin-4 activates two distinct pathways of phosphatidylinositol-3 kinase in the same cells                             
Biochemical and Biophysical Research Communications, 229:624-629, 1996

8. Izuhara K, Feldman RA, Greer P, Harada N:
Interleukin-4 induces association of the c-fes proto-oncogene product with phosphatidylinositol-3 kinase
Blood, 88:3910-3918, 1996

7. Schultz C, Izuhara K, Coffman R, Harada N:
The critical region in the cytoplasmic domain of human IL-4 receptor for induction of IgE synthesis
Immunology Letters, 46:215-219, 1995

6.Izuhara K, Sakai M, Inaba R, Imamura T, Howard M, Harada N:
A synthetic peptide corresponding to a critical intracellular signalling region of the human IL-4 receptor inhibits IL-4-dependent proliferation
Cellular Immunology, 163:254-259, 1995

5. Izuhara K, Ideguchi H, Ohtsuka T, Okubo K, Ogo T, Hamasaki N, Niho Y:
High incidence of a polymorphic variant of erythrocyte membrane protein, Band 3-Memphis, on a western Japanese island
Journal of Human Genetics (formerly The Japanese Journal of Human Genetics), 40:265-270, 1995

4. Izuhara K, Feldman RA, Greer P, Harada N:
Interaction of the c-fes proto-oncogene product with the interleukin-4 receptor
Journal of Biological Chemistry, 269:18623-18629, 1994

3. Izuhara K, Yang G, Miyajima A, Howard M, Harada N:
Structure of the IL4 receptor and signal transduction mechanism of IL4           
Research in Immunology, 144:584-589, 1993

2. Izuhara K, Harada N:
Interleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of phosphatidylinositol 3-Kinase to the IL-4 receptor in a mouse T cell line, HT2                           
Journal of Biological Chemistry, 268:13097-13102, 1993

1. IIzuhara K, Miyajima A, Harada N:
The chimeric receptor between ineterleukin-2 receptor b chain and interleukin-4 receptor transduces interleukin-2 signal
Biochemical and Biophysical Research Communications, 190:992-1000, 1993



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Div. Medical Biochemistry, Saga Med. Sch.