原著

1. Higashimoto K, Sun F, Imagawa E, Saida K, Miyake N, Hara S, Yatsuki H, Kubiura-Ichimaru M, Fujita A, Mizuguchi T, Matsumoto N, Soejima H. Whole exome sequencing reveals causative genetic variants for several overgrowth syndromes in Beckwith–Wiedemann spectrum with negative molecular testing. Journal of Medical Genetics, 2024 (in press)

原著

1. Onizuka M, Imanishi T, Harada K, Aoyama Y, Amaki J, Toyosaki M, Machida S, Kikkawa E, Yamada S, Nakabayashi K, Hata K, Higashimoto K, Soejima H, Ando K. Donor cord blood aging accelerates in recipients after transplantation. Scientific Reports, 13(1):2603, 2023 (Open access)
2. Yamamoto Y, Higashimoto K, Ohkawa Y, Soejima H, Kaneko K, Ohmi Y, Furukawa K, Furukawa K. Possible regulation of ganglioside GD3 synthase gene expression with DNA methylation in human glioma cells. Glycoconj J. 2023 Online ahead of print.

総説

1. 原聡史, 副島英伸. 基礎編 エピジェネティクス. 腎と透析 特集：Genetics in CKD, 94(3):246-253, 東京医学社, 東京, 2023

著書

原著

1. Aoki S, Higashimoto K. Hidaka H, Ohtsuka Y, Aoki S, Mishima H, Yoshiura K, Nakabayashi K, Hata K, Yatsuki H, Hara S, Ohba T, Katabuchi H, Soejima H. Aberrant hypomethylation at imprinted differentially methylated regions is involved in biparental placental mesenchymal dysplasia. Clinical Epigenetics, 14(1):64, 2022 (Open access)
2. Hirata H, Kamohara A, Murayama M, Nishioka K, Honda H, Urano Y, Soejima H, Oki S, Kukita T, KawanoS, Mawatari M, Kukita A. A novel role of helix-loop-helix transcriptional factor Bhlhe40 in osteoclast activation. J Cell Physiol, 237(10):3912-3926, 2022. (Open access)

総説

1. Soejima H, Hara S, Ohba T, Higashimoto K. Placental Mesenchymal Dysplasia and Beckwith-Wiedemann Syndrome. Cancers, 14:5563, 2022.
2. 副島英伸．Beckwith-Wiedemann症候群とSotos症候群．特集：知っておくべき周産期・新生児領域の遺伝学的検査を展望する　周産期医学52(5):755-759, 2022

著書

1. Higashimoto K, Hara S, Soejima H. Chapter 1: DNA Methylation Analysis Using Bisulfite Pyrosequencing. Methods in Molecular Biology. Springer, 2022.

原著

1. Kodera C, Aoki S, Ohba T, Higashimoto K, Mikami Y, Fukunaga M, Soejima H, Katabuchi H. Clinical manifestations of placental mesenchymal dysplasia in Japan: A multicenter case series. The Journal of Obstetrics and Gynaecology Research, 47(3):1118-1125, 2021
2. Hara S, Terao M, Tsuji-Hosokawa A, Ogawa Y, Takada S. Humanization of a tandem repeat in IG-DMR causes stochastic restoration of paternal imprinting at mouse Dlk1-Dio3 domain. Human Molecular Genetics, 30(7):564-574, 2021 (Open access)
3. Mori H, Takahashi H, Mine K, Higashimoto K, Inoue K, Kojima M, Kuroki S, Eguchi T, Ono Y, Inuzuka S, Soejima H, Nagafuchi S, Anzai K. TYK2 promoter variant is associated with impaired insulin secretion and lower insulin resistance in Japanese type 2 diabetes patients. Genes, 12(3):400, 2021 (Open access)
4. Higashimoto K, Watanabe H, Tanoue Y, Tonoki H, Tokutomi T, Hara S, Yatsuki H, Soejima H. Hypomethylation of a centromeric block of ICR1 is sufficient to cause Silver-Russell syndrome. Journal of Medical Genetics 58(6):422-425, 2021 (Open Access)
5. Koganebuchi K, Sato K Fujii K, Kumabe T, Haneji K, Toma T, Ishida H, Joh K, Soejima H, Mano S, Ogawa M, Oota H. An analysis of the demographic history of the risk allele R4810K in RNF213 of moyamoya disease. Annals of Human Genetics, 2021 (Open access)
6. Sun F, Hara S, Tomita C, Tanoue Y, Yatsuki H, Higashimoto K, Soejima H. Phenotypically concordant but epigenetically discordant monozygotic dichorionic diamniotic twins with Beckwith-Wiedemann syndrome. American Journal of Medical Genetics Part A, 185(10):3062-3067, 2021.
7. Tomiga Y, Sakai K, Ra SG, Kusano M, Ito A, Uehara Y, Takahashi H, Kawanaka K, Soejima H, Higaki Y. Short-term running exercise alters DNA methylation patterns in nNOS and BDNF genes in the mouse hippocampus and reduces anxiety-like behaviours. FASEB Journal, 35(8):e21767, 2021 (Open Access）

著書

1. Soejima H, and Ohba T. Chapter 11 Genomic Imprinting Disorders (Including Mesenchymal Placental Dysplasia), Masuzaki H (ed.) Fetal Morph Functional Diagnosis. Springer, 2021
2. 原聡史, 副島英伸. DNAメチル化の分子機構. 遺伝子医学MOOK36　エピゲノムで新たな解明が進む「先天性疾患」, 編集：副島英伸, 秦健一郎, メディカルドゥ, 大阪, pp20-26, 2021
3. 副島英伸. Beckwith-Wiedemann症候群/Silver-Russell症候群. 遺伝子医学MOOK36　エピゲノムで新たな解明が進む「先天性疾患」, 編集：副島英伸, 秦健一郎, メディカルドゥ, 大阪, pp60-66, 2021
4. 東元健, 副島英伸. Sotos症候群. 遺伝子医学MOOK36　エピゲノムで新たな解明が進む「先天性疾患」, 編集：副島英伸, 秦健一郎, メディカルドゥ, 大阪, pp105-109, 2021
5. 副島英伸. Lecture（臨床遺伝学・人類遺伝学誌上講義）「エピゲノム」. 遺伝子医学38号（Vol.11, No.4）, メディカルドゥ, 大阪, pp108-115,2021

原著

1. Watanabe H, Higashimoto K, Miyake N, Morita S, Horii T, Kimura M, Suzuki T, Maeda T, Hidaka H, Aoki S, Yatsuki H Okamoto N, Uemura T, Hatada I Matsumoto N, Soejima H. DNA methylation analysis of multiple imprinted DMRs in Sotos syndrome reveals IGF2-DMR0 as a DNA methylation-dependent, P0 promoter-specific enhancer. FASEB J 34(1):960-973, 2020 (Open Access)

原著

1. Yamada T, Sugiyama G, Higashimoto K, Nakashima A, Nakano H, Sumida T, Soejima H, Mori Y. Beckwith-Wiedemann syndrome with asymmetrical mosaic of paternal disomy causing hemihyperplasia. Oral Surg Oral Med Oral Pathol Oral Radiol, 127(3):e84-e88, 2019 (Open Access)
2. Sun F, Higashimoto K, Awaji A, Ohishi K, Nishizaki N, Tanoue Y, Aoki S, Watanabe H, Yatsuki H, Soejima H. The extent of DNA methylation anticipation due to a genetic defect in ICR1 in Beckwith-Wiedemann syndrome. J Hum Genet, 64(9):937-943, 2019
3. Nishida Y, Hara M, Higaki Y, Taguchi N, Nakamura K, Nanri H, Horita M, Shimanoe C, Yasukata J, Miyoshi N, Yamada Y, Higashimoto K, Soejima H, and Tanaka K. Habitual light-intensity physical activity and ASC methylation in a middle-aged population. Int J Sports Med, 40(10):670-677, 2019
4. Tomiga Y, Ito A, Sudo M, Ando S, Eshima H, Sakai K, Nakashima S, UeharaY, Tanaka H, Soejima H, Higaki Y. One-week, but not 12-hours, cast immobilization alters promotor DNA methylation patterns in the nNOS gene in mouse skeletal muscle. J Physiol, 597(21):5145-5159, 2019
5. Hara S, Terao M, Muramatsu A, Takada S. Efficient production and transmission of CRISPR/Cas9-mediated mutant alleles at the IG-DMR via generation of mosaic mice using a modified 2CC method. Scientific Reports, 9(1):20202, 2019(Open Access)

総説

1. Acharya G, Bartolomei M, Carter AM, Chamley L, Cotton CF, Hasegawa J, Hasegawa Y, Hayakawa S, Kawaguchi M, Konwar C, Magawa S, Miura K, Nishi H, Salomon C, Sato K, Soejima H, Soma H, Sørensen A, Takahashi H, Tomita T, Whittington CM, Yuan V, O'Tierney-Ginn P. IFPA meeting 2018 workshop report I: Reproduction and placentation among ocean-living species; placental imaging; epigenetics and extracellular vesicles in pregnancy. Placenta. 2019 Feb 10. pii: S0143-4004(18)31201-3. (Review)

原著

1. Kawasaki Y, Makimoto M, Samejima A, Yoneda N, Higashimoto K, Soejima H, Yoshida T. Hepatoblastoma in an extremely low birth-weight infant with Beckwith-Wiedemann Syndrome. Pediatr Neonatol. 59(5):523-524, 2018(Open Access)
2. Nishioka K, Wang XF, Miyazaki H, Soejima H, Hirose S. Mbf1 ensures Polycomb silencing by protecting E(z) mRNA from degradation by Pacman. Development, 145(5), 2018 (Open Access)
3. Joh K, Matsuhisa F, Kitajima S, Nishioka K, Higashimoto K, Yatsuki H, Kono T, Koseki H, Soejima H. Growing oocyte specific transcription-dependent de novo DNA methylation at the imprinted Zrsr1-DMR. Epigenetics Chromatin, 11:28, 2018 (Open Access)
4. Nishioka K, Miyazaki H, Soejima H. Unbiased shRNA screening, using a combination of FACS and high-throughput sequencing, enables identification of novel modifiers of Polycomb silencing. Scientific Reports, 8(1):12128, 2018 (Open Access)
5. Hidaka H, Higashimoto K, Aoki S, Mishima H, Hayashida C, Maeda T, Koga Y, Yatsuki H, Joh K, Noshiro H, Iwakiri R, Kawaguchi A, Yoshiura KI, Fujimoto K, Soejima H. Comprehensive methylation analysis of imprinting-associated differentially methylated regions in colorectal cancer. Clin Epigenet, 10:150, 2018(Open Access)
6. Castiglioni I, Caccia R, Garcia-Manteiga JM, Ferri G, Caretti G, Molineris I, Nishioka K, Gabellini D.The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression. Nat Commun. 9(1):5026, 2018(Open Access)

総説

1. 副島英伸．Beckwith-Wiedemann症候群．産科と婦人科．85(6):667-672, 2018

著書

1. 副島英伸．第６講義エピジェネティクス　コアカリ準拠臨床遺伝学テキストノート　日本人類遺伝学会編集　診断と治療社　東京　pp72-83　2018

原著

1. Imagawa E, Higashimoto K, Sakai Y, Numakura C, Okamoto N, Matsunaga S, Ryo A, Sato Y, Sanefuji M, Ihara K, Takada Y, Nishimura G, Saitsu H, Mizuguchi T, Miyatake S, Nakashima M, Miyake N, Soejima H, Matsumoto N. Mutations in Genes Encoding Polycomb Repressive Complex 2 Subunits Cause Weaver Syndrome. Hum Mutat, 38(6):637-648, 2017
2. Koganebuchi K, Haneji K, Toma T, Joh K, Soejima H, Fujimoto K, Ishida H, Ogawa M, Hanihara T, Harada S, Kawamura S, Oota H. The allele frequency of ALDH2*Glu504Lys and ADH1B*Arg47His for the Ryukyu islanders and their history of expansion among East Asians. Am J Hum Biol, 29(2), 2017
3. Soma N*, Higashimoto K*, Imamura M, Saitoh A, Soejima H, Nagasaki K. (*: contributed equally) Long term survival of a patient with Perlman syndrome due to novel compound heterozygous missense mutations in RNB domain of DIS3L2 . Am J Med Genet Part A, 173(4) :1077-1081, 2017
4. Akiyama T, Katsumura T, Nakagome S, Lee SI, Joh K, Soejima H, Fujimoto K, Kimura R, Ishida H, Hanihara T, Yasukouchi A, Satta Y, Higuchi S, Oota H. An ancestral haplotype of the human PERIOD2 gene associates with reduced sensitivity to light-induced melatonin suppression. PLoS One, 12(6):e0178373, 2017 (Open Access)
5. Takamatsu Y, Higashimoto K, Maeda T, Kawashima M, Matsuo M, Abe T, Matsushima T, Soejima H. Differences in the genotype frequency of the RNF213 variant in familial moyamoya disease patients in Kyushu, Japan. Neurol Med Chir, 57(11): 607–611, 2017 (Open Access)
6. Hori I, Kawamura R, Nakabayashi K, Watanabe H, Higashimoto K, Ieda D, Ohashi K, Negishi Y, Hattori A, Sugio Y, Wakui K, Hata K, Soejima H, Kurosawa K, Saitoh S. CTCF deletion syndrome: clinical features and epigenetic delineation. J Med Genet , 54(12): 836–842, 2017 (Open Access)

総説

1. 大塚泰史、副島英伸．モザイク病、インプリンティング．腎と透析．82(3):356-362, 2017
2. 副島英伸．ゲノムインプリンティングの制御機構とインプリンティング疾患の発症機序．医学のあゆみ．263(4):281-286, 2017

著書

1. Higashimoto K, Joh K, Soejima H. Genomic Imprinting Syndromes and Cancer, Part III DNA and Histone Methylation-Related Events Underlying Cancer, Kaneda A and Tsukada Y (eds.) DNA and Histone Methylation as Cancer Targets. New York, Humana Press, pp297-344, 2017

原著

1. Rumbajan JM, Yamaguchi Y, Nakabayashi K, Higashimoto K, Yatsuki H, Nishioka K, Matsuoka K, Aoki S, Toda S, Takeda S, Seki H, Hatada I, Hata K, Soejima H, Joh K. The HUS1B promoter is hypomethylated in the placentas of low-birth-weight infants. Gene, 583(2):141-146, 2016
2. Ohtsuka Y, Higashimoto K, Oka T, Yatsuki H, Jozaki K, Maeda T Kawahara K, Hamasaki Y, Matsuo M, Nishioka K, Joh K, Mukai T, Soejima H. Identification of consensus motifs associated with mitotic recombination and clinical characteristics in patients with paternal uniparental isodisomy of chromosome 11. Hum Mol Genet, 25(7):1406–1419, 2016
3. Ito Y, Maehara K, Kaneki E, Matsuoka K, Sugahara N, Miyata T, Kamura H, Yamaguchi Y, Kono A, Nakabayashi K, Migita O, Higashimoto K, Soejima H, Okamoto A, Nakamura H, Kimura T, Wake N, Taniguchi T, Hata K. Novel Nonsense Mutation in the NLRP7 Gene Associated with Recurrent Hydatidiform Mole. Gynecol Obstet Invest, 81(4):353-358, 2016

原著

1. Ohtsuka Y, Higashimoto K, Sasaki K, Jozaki K, Yoshinaga H, Okamoto N, Takama Y, Kubota A, Nakayama M, Yatsuki H, Nishioka K, Joh K, Mukai T, Yoshiura KI, Soejima H. Autosomal recessive cystinuria caused by genome-wide paternal uniparental isodisomy in a patient with Beckwith-Wiedemann syndrome. Clin Genet, 88(3):261-266, 2015 (Open Access)

総説

1. 東元健、副島英伸．Beckwith-Wiedemann 症候群（BWS）．臨床画像．31(10増刊号):189-191, 2015
2. 東元健、副島英伸．Beckwith-Wiedemann syndrome．日本臨床 家族性腫瘍学—家族性腫瘍の最新研究動向—．73(増刊号6):59-63, 2015

原著

1. Court F, Tayama C, Romanelli V, Martin-Trujillo A, Iglesias-Platas I, Okamura K, Sugahara N, Simón C, Moore H, Harness JV, Keirstead H, Sanchez-Mut JV, Kaneki E, Lapunzina P, Soejima H, Wake N, Esteller M, Ogata T, Hata K, Nakabayashi K, Monk D. Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of the human imprintome and suggests a germline methylation independent establishment of imprinting. Genome Res., 24(4):554-569, 2014 (Open Access)
2. Ohnishi K, Semi K, Yamamoto T, Shimizu M, Tanaka A, Mitsunaga K, Okita K, Osafune K, Arioka Y, Maeda T, Soejima H, Moriwaki H, Yamanaka S, Woltjen K, Yamada Y. Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Cell, 156(4), 663–677, 2014 (Open Access)
3. Takama Y, Kubota A, Nakayama M, Higashimoto K, Jozaki K, Soejima H. Fibroadenoma in a Beckwith-Wiedemann syndrome with paternal uniparental disomy of chromosome 11p15.5. Pediatr Int, 56(6):931-934, 2014
4. Maeda T, Higashimoto K, Jozaki K, Yatsuki H, Nakabayashi K, Makita Y, Tonoki H, Okamoto N, Takada F, Ohashi H, Migita M, Kosaki R, Matsubara K, Ogata T, Matsuo M, Hamasaki Y, Ohtsuka Y, Nishioka K, Joh K, Mukai T, Hata K, Soejima H. Comprehensive and quantitative multilocus methylation analysis reveals the susceptibility of specific imprinted differentially methylated regions (DMRs) to aberrant methylation in Beckwith-Wiedemann syndrome with epimutations. Genet Med, 16(12):903-912, 2014 (Open Access)
5. Higashimoto K, Jozaki K, Kosho T, Matsubara K, Fuke T, Yamada D, Yatsuki H, Maeda T, Ohtsuka Y, Nishioka K, Joh K, Koseki H, Ogata T, Soejima H. A novel de novo point mutation of the OCT-binding site in the IGF2/H19-imprinting control region in a Beckwith-Wiedemann syndrome patient. Clin Genet, 86(6):539-544, 2014 (Open Access)

総説

1. 大場隆、片渕秀隆、副島英伸．間葉性異形成胎盤Placental mesenchymal dysplasia (PMD)の診断と原因遺伝子．病理と臨床 32(5):535-540, 2014

著書

1. 西岡憲一．エピジェネティクスの産業応用　第Ⅱ編基礎研究　第2章ヒストン修飾による遺伝子発現制御機構　監修：畑田出穂・久保田健夫、シーエムシー出版、東京、pp35-60, 2014
2. 副島英伸．エピジェネティクスの産業応用　第Ⅳ編疾患エピゲノム研究　第12章インプリンティング疾患のエピジェネティクス　監修：畑田出穂・久保田健夫、シーエムシー出版、東京、pp266-279, 2014
3. 東元健、副島英伸．Beckwith-Wiedemann症候群．別冊日本臨牀　新領域別症候群シリーズNo.29　神経症候群（第２版）Ⅳ–その他の神経疾患を含めて–　日本臨牀社、大阪、498-501, 2014
4. 前田寿幸、副島英伸． Silver-Russell症候群．別冊日本臨牀　新領域別症候群シリーズNo.29　神経症候群（第２版）Ⅳ–その他の神経疾患を含めて–　日本臨牀社、大阪、685-688, 2014

原著

1. Yatsuki H, Higashimoto K, Jozaki K, Koide K, Okada J, Watanabe Y, Okamoto N, Tsuno Y, Yoshida Y, Ueda K, Shimizu K, Ohashi H, Mukai T, Soejima H. Novel Mutations of CDKN1C in Japanese Patients with Beckwith-Wiedemann Syndrome. Genes & Genomics, 35(2):141-147, 2013
2. Adachi H, Takahashi I, Higashimoto K, Tsuchida S, Noguchi A, Tamura H, Arai H, Ito T, Masue M, Nishibori H, Takahashi T, Soejima H. Congenital hyperinsulinism in an infant with paternal uniparental disomy on chromosome 11p15: Few clinical features suggestive of Beckwith-Wiedemann syndrome. Endocr J., 60(4):403-408, 2013
3. Misago N, Joh K, Soejima H, Narisawa Y. Multiple mucocutaneous (palisaded encapsulated) neuromas may be a distinct entity. JAMA Dermatol, 149(4):498-500, 2013
4. Soejima H, Higashimoto K. Epigenetic and genetic alterations of the imprinting disorder Beckwith-Wiedemann syndrome and related disorders. J Hum Genet, 58(7): 402-409, 2013
5. Fukuda K, Ichiyanagi K, Yamada Y, Go Y, Udono T, Wada S, Maeda T, Soejima H, Saitou N, Ito T, Sasaki H. Regional DNA methylation differences between humans and chimpanzees are associated with genetic changes, transcriptional divergence and disease genes. J Hum Genet, 58(7):446-454, 2013
6. Higashimoto K†, Maeda T†, Okada J†, Ohtsuka Y, Sasaki K, Hirose A, Nomiyama M, Takayanagi T, Fukuzawa R, Yatsuki H, Koide K, Nishioka K, Joh K, Watanabe Y, Yoshiura K, Soejima H. Homozygous deletion of DIS3L2 exon 9 due to non-allelic homologous recombination between LINE-1s in a Japanese patient with Perlman syndrome. Eur J Hum Genet, 21(11):1316-1319, 2013
7. Miyazaki H†, Higashimoto K†, Yada Y†, A. Endo T¶, Sharif J¶, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K. Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract Polycomb silencing. PLoS Genet, 9(11):e1003897, 2013 (†, ¶ equal contribution)
8. Rumbajan JM, Maeda T, Souzaki R, Mitsui K, Higashimoto K, Nakabayashi K, Yatsuki H, Nishioka K, Harada R, Aoki S, Kohashi K, Oda Y, Hata K, Saji T, Taguchi T, Tajiri T, Soejima H, Joh K. Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma. BMC Cancer, 13:608, 2013 (Open Access)

総説

1. 副島英伸．Beckwith-Wiedemann症候群，Sotos症候群．周産期医学 43(3):377-382, 2013
2. 前田寿幸、東元健、副島英伸．Beckwith-Wiedemann症候群とSilver-Russell症候群．小児科臨床 66(増刊号):1308-1314, 2013

著書

1. 東元健、副島英伸．Beckwith-Wiedemann症候群と小児腫瘍．遺伝子医学MOOK25　エピジェネティクスと病気　監修：佐々木裕之、編集：中尾光善、中島欽一、メディカルドゥ、大阪、pp195-201, 2013

原著

1. Higashimoto K, Nakabayashi K, Yatsuki H, Yoshinaga H, Jozaki K, Okada J, Watanabe Y, Aoki A, Shiozaki A, Saito S, Koide K, Mukai T, Hata K, Soejima H. Aberrant methylation of H19-DMR acquired after implantation was dissimilar in soma versus placenta of patients with Beckwith-Wiedemann syndrome. Am J Med Genet Part A, 158A:1670-1675, 2012
2. Hiura H, Okae H, Miyauchi N, Sato F, Sato A, Van De Pette M, John RM, Kagami M, Nakai K, Soejima H, Ogata T, Arima T. Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies. Hum Reprod, 27(8):2541-2548, 2012

原著

1. Al-Dhaheri M, Wu J, Skliris GP, Li J, Higashimato K, Wang Y, White KP, Lambert P, Zhu Y, Murphy L, Xu W. CARM1 is an important determinant of ERα-dependent breast cancer cell differentiation and proliferation in breast cancer cells. Cancer Res., 71(6):2118-2128, 2011
2. Nagae G, Isagawa T, Shiraki N, Fujita T, Yamamoto S, Tsutsumi S, Nonaka A, Yoshiba S, Matsusaka K, Midorikawa Y, Ishikawa S, Soejima H, Fukayama M, Suemori H, Nakatsuji N, Kume S, Aburatani H. Tissue-specific demethylation in CpG-poor promoters during cellular differentiation. Hum Mol Genet, 20(14):2710-2721, 2011
3. Nakabayashi K, Trujillo AM, Tayama C, Camprubi C, Yoshida W, Lapunzina P, Sanchez A, Soejima H, Aburatani H, Nagae G, Ogata T, Hata K, Monk D. Methylation screening of reciprocal genome-wide UPDs identifies novel human specific imprinted genes. Hum Mol Genet, 20(16):3188-3197, 2011
4. Aoki A, Shiozaki A, Sameshima A, Higashimoto K, Soejima H, Saito S. Beckwith-Wiedemann Syndrome with Placental Chorangioma due to H19-DMR Hypermethylation: A Case Report. J Obstet Gynaecol Res, 37(12):1872-1876, 2011
5. ato S, Yoshida W, Soejima H, Nakabayashi K, Hata K. Methylation dynamics of IG-DMR and Gtl2-DMR during murine embryonic and placental development. Genomics, 98(2):120-127, 2011

著書

1. 副島英伸．ベックウィズ・ヴィーデマン症候群、シルバー・ラッセル症候群　第XIV章 　先天異常・奇形　症候群ハンドブック．井村裕夫総編集，福井次矢・辻省次 編集．中山書店．東京．Pp679 & 685, 2011

原著

1. Yamamoto S, Toyama D, Yatsuki H, Higashimoto K, Soejima H, Isoyama K. Acute megakaryocytic leukemia (AMKL,FAB;M7) with Beckwith-wiedemann syndrome. Pediatr Blood Cancer, 55(4):733-735, 2010
2. Uchihashi K, Aoki S, Shigematsu M, Kamochi N, Sonoda Emiko, Soejima H, Fukudome K, Sugihara H, Hotokebuchi T, Toda S. Organotypic culture of human bone marrow adipose tissue for analyzing its biological roles. Pathol Int, 60(4):259-267, 2010

著書

1. 西岡憲一．12章トリソラックス群タンパク質による転写制御　エピジェネティクス．D. アリス・T. ジェニュワイン・D. ラインバーグ共編，堀越正美監訳．培風館．東京．Pp269-290, 20101
2. 副島英伸，城圭一郎，中尾光善．23章エピジェネティクスとヒト疾患　エピジェネティクス．D. アリス・T. ジェニュワイン・D. ラインバーグ共編，堀越正美監訳．培風館．東京．Pp505-528, 2010

原著

1. Joh K†, Yatsuki H†, Higashimoto K, Mukai T, Soejima H. Antisense transcription occurs at the promoter of a mouse imprinted gene, Commd1, on the repressed paternal allele. J Biochem, 146(6):771-774, 2009 († equal contribution)

総説

1. 副島英伸．第53回九州地方会特別講演１ エピジェネティクス関連疾患と解析方法．臨床病理．57(8): 769-778, 2009
2. 東元　健、副島英伸．小児科 特集小児疾患における臨床遺伝学の進歩． Beckwith-Wiedemann症候群．50(7): 1046-1052, 2009
3. 副島英伸．Wiedemann-Beckwith症候群．新川詔夫，緒方勤監修 ビジュアル疾患解説 目で見る遺伝病とターナー症候群 No．5: 6-7, 2009 株式会社メディアート

著書

1. 副島英伸．第２部ゲノミクス　カラー図解基礎から疾患までわかる遺伝学．新川詔夫，吉浦孝一郎監訳．メディカル・サイエンス・インターナショナル．東京．Pp240-269, 2009

原著

1. Nomura T, Kimura M, Horii T, Morita S, Soejima H, Kudo S, Hatada I. MeCP2-dependent repression of an imprinted miR-184 released by depolarization. Hum. Mol. Genet., 17, 1192-1199, 2008.
2. Haruta M, Arai Y, Sugawara W, Watanabe N, Honda S, Ohshima J, Soejima H, Nakadate H, Okita H, Hata J, Fukuzawa M, Kaneko Y. Duplication of paternal IGF2 or loss of maternal IGF2 imprinting occurs in half of Wilms tumors with various structural WT1 abnormalities.Genes Chromosomes Cancer, 47, 712-727, 2008.
3. Yakabe S, Soejima H, Yatsuki H, Tominaga H, Zhao W, Higashimoto K, Joh K, Kudo S, Miyazaki K, Mukai T. MeCP2 knockdown reveals DNA methylation-independent gene repression of target genes in living cells and a bias in the cellular location of target gene products. Genes Genet. Syst., 83, 199-208, 2008.
4. Misago N, Joh K, Yatsuki H, Soejima H, Narisawa Y. A BHD Germline Mutation Identified in an Asian Family with Birt-Hogg-Dube Syndrome.　Acta Dermato-Venereologica, 88, 423-425, 2008.
5. Sonoda E, Aoki S, Uchihashi K, Soejima H, Kanaji S, Izuhara K, Satoh S, Fujitani N, Sugihara H, Toda S. A new organotypic culture of adipose tissue fragments maintains viable mature adipocytes for a long term, together with development of immature adipocytes and mesenchymal stem cell-like cells.Endocrinology, 149, 4794-4798, 2008.

総説

1. 副島英伸．特集エピジェネティクス−最近の動向と疾患−　ゲノムインプリンティング異常と疾患、最新医学 、63, 83-90, 200
2. 副島英伸．ゲノムインプリンティング機構と疾患　臨床検査 、56, 683-688, 2008．
3. 東元 健,副島英伸．ゲノム刷り込みとBeckwith-Wiedemann症候群　日本小児血液学会雑誌、22, 139-143, 2008

著書

1. 西岡憲一、エピジェネティクス実験プロトコール（羊土社）、181-189, 2008

原著

1. Zhang Z, Joh K, Yatsuki H, Zhao W, Soejima H, Higashimoto K, Noguchi M, Yokoyama M, Iwasaka T, Mukai T. Retinoic acid receptor β2 is epigenetically silenced either by DNA methylation or repressive histone modifications at the promoter in cervical cancer cells. Cancer Lett., 247, 318-327, 2007.
2. Yamasaki-Ishizaki Y, Kayashima T, Mapendano CK, Soejima H, Ohta T, Masuzaki H, Kinoshita A, Urano T, Yoshiura K, Matsumoto N, Ishimaru T, Mukai T, Niikawa N, Kishino T. Role of DNA methylation and histone H3 Lysine 27 methylation in tissue-specific imprinting of mouse Grb10.Mol. Cell. Biol., 27, 732-742, 2007.
3. Watanabe N, Haruta M, Soejima H, Fukushi D, Yokomori K, Nakadate H, Okita H, Hata J, Fukuzawa M, Kaneko Y. Duplication of the paternal IGF2 allele in trisomy 11 and elevated expression levels of IGF2 mRNA in congenital mesoblastic nephroma of the cellular or mixed type. Gene Chromosome Cancer, 46, 929-935, 2007.
4. Sasaki K, Soejima H, Higashimoto K, Yatsuki H, Ohashi H, Yakabe S, Joh K, Niikawa N, Mukai T. Japanese and North American/European patients with Beckwith-Wiedemann syndrome have different frequencies of some epigenetic and genetic alterations.Eur. J. Hum. Genet., 15, 1205-1210, 2007.
5. Higashimoto K, Kuhn P, Desai D, Cheng X, Xu W. Phosphorylation-mediated inactivation of coactivator-associated arginine mehyltransferase 1. Proc. Natl. Acad. Sci., 104, 12318-12323, 2007.

総説

1. 副島英伸．ヒストン修飾の個別およびゲノム網羅的解析法～ChIP法とChIP on chip法、特集エピジェネティクスの最新テクノロジー・バイオテクノロジージャーナル, 7, 433-439, 2007．

原著

1. Higashimoto K, Soejima H, Saito T, Okumura K, Mukai T. Imprinting disruption of the KIP2/LIT1 domain: the molecular mechanism causing Beckwith-Wiedemann syndrome and cancer. Cytogenet. Genome Res., 113, 306-312, 2006.
2. Higashimoto I, Yoshiura K.I., Hirakawa N, Higashimoto K, Soejima H, Totoki T, Mukai T, Niikawa N. A primary palmar hyperhidrosis locus maps to 14q11.2-q13.Am. J. Med. Genet., 140, 567-572, 2006.
3. Nakano S, Murakami K, Meguro M, Soejima H, Higashimoto K, Urano T, Kugoh H, Mukai T, Ikeguchi M, Oshimura M. Expression profile of LIT1/KCNQ1OT1 and epigenetic status at the KvDMR1 in colorectal cancers. Cancer Science, 97, 1147-1154, 2006.
4. Satoh Y, Nakadate H, Nakagawachi T, Higashimoto K, Joh K, Masaki Z, Uozumi J, Kaneko Y, Mukai T, Soejima H. Genetic and epigenetic alterations on the short arm of chromosome 11 are involved in a majority of sporadic Wilms' tumors.Brit. J. Cancer, 95, 541-547, 2006.
5. Watanabe N, Nakadate H, Haruta M, Sugawara W, Sasaki F, Tsunematsu Y, Kikuta A, Fukuzawa M, Okita H, Hata J, Soejima H, Kaneko Y. Association of 11q loss, trisomy 12 and possible 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor.Genes Chromosomes Cancer , 45, 592-601, 2006.
6. Yamada Y, Shirakawa T, Taylor TD, Okamura K, Soejima H, Uchiyama M, Iwasaka T, Mukai T, Muramoto K, Sakaki Y, Ito T. A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 11q: Comparison with chromosome 21q.DNA Sequence, 17, 300-306, 2006.
7. Zhang Z, Joh K, Yatsuki H, Wang Y, Arai Y, Soejima H, Higashimoto K, Iwasaka T, Mukai T. Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in mice.Gene, 366, 77-86, 2006.

著書

1. 副島英伸，太田　亨，向井常博．（中尾光善、塩田邦郎、牛島俊和、佐々木裕之編）第５章 エピジェネティクスと疾患．４．インプリンティング関連疾患．実験医学増刊ゲノムワイドに展開するエピジェネティクス医科学．羊土社．東京　2006．

原著

1. Yamasaki Y, Kayashima T, Soejima H, Kinoshita A, Yoshiura K, Matsumoto N, Ohta T, Urano T, Masuzaki H, Ishimaru T, Mukai T, Niikawa N, Kishino T. Neuron-specific relaxation of Igf2r imprinting is associated with neuron-specific histone modifications and lack of its antisense transcript Air. Hum Mol Genet, 14(17): 2511-2520, 2005
2. Koga Y, Kitajima Y, Miyoshi A, Sato K, Kitahara K, Soejima H, Miyazaki K. Tumor progression through epigenetic gene silencing of O6-methylguanine-DNA methyltransferase in human biliary tract cancers. Ann Surg Oncol, 12(5): 354-363, 2005
3. Arima T, Kamikihara T, Hayashida T, Kato K, Inoue T, Shirayoshi Y, Oshimura M, Soejima H, Mukai T, Wake N. ZAC, LIT1 (KCNQ1OT1) and p57^KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith–Wiedemann syndrome. Nucleic Acids Res, 33(8): 2650–2660, 2005
4. Sato K, Kitajima Y, Nakagawachi T, Soejima H, Miyoshi A, Koga Y, Miyazaki K. Cisplatin represses transcriptional activity from the minimal promoter of the O(6)-methylguanine methyltransferase gene and increases sensitivity of human gallbladder cancer cells to 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-2-chloroethyl)-3-nitrosourea. Oncol Rep, 13(5): 899-906, 2005
5. Zhao W, Soejima H, Higashimoto K, Nakagawachi T, Urano T, Kudo S, Matsukura S, Matsuo S, Joh K, Mukai T. The Essential Role of Histone H3 Lys9 Methylation and MeCP2 Binding in MGMT Silencing with Poor DNA Methylation of the Promoter CpG Island. J Biochem, 137(3): 431-440, 2005

総説

1. Soejima H, Zhao W, Mukai T. Epigenetic silencing of the MGMT gene in cancer. Biochem Cell Biol, 83(4): 429-437, 2005
2. Soejima H, Wagstaff J. Imprinting, Chromatin Structure, and Disease. J Cell Biochem, 95(2): 226-233, 2005
3. 副島英伸，東元　健，向井常博．インプリンティングと先天異常、癌．Molecular Medicine, 42(2): 201-208, 2005

原著

1. Shirohzu H, Yokomine T, Sato C, Kato R, Toyoda A, Purbowasito W, Suda C,Mukai T, Hattori M, Okumura K, Sakaki Y, Sasaki H A 210-kb segment oftandem repeats and retroelements located between imprinted subdomains ofmouse distal chromosome 7. DNA Res., 11, 325-334, 2004.
2. Wang Y, Joh K, Masuko S, Yatsuki H, Soejima H, Nabetani A, Beechey CV, Okinami S, Mukai T. Mouse Murr1 gene is imprinted in the adult brain, presumably due to transcriptional interference by the antisense-oriented U2af1-rs1 gene. Molecular Cellular Biology, 24 (1), 270-279, 2004.
3. Soejima H, Nakagawachi T, Zhao W, Higashimoto K, Urano T, Matsukura S, Kitajima Y, Takeuchi M, Nakayama M, Oshimura M, Miyazaki K, Joh K, Mukai T. Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer.Oncogene, 23 (25), 4380-4388, 2004
4. Yamada Y, Watanabe H, Miura F, Soejima H, Uchiyama M, Iwasaka T, Mukai T, Sakaki Y, Ito T. A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 21q. Genome Res., 14 (2), 247-266, 2004
5. Satoh A, Toyota M, Ikeda H, Morimoto Y, Akino K, Mita H, Suzuki H, Sasaki Y, Kanaseki T, Takamura Y, Soejima H, Urano T, Yanagihara K, Hinoda Y, Endo T, Fujita M, Hosokawa M, Sato N, Tokino T, Imai K. Epigenetic Inactivation of Class II Transactivator (CIITA) is Associated with the Absence of Interferon-g-Induced HLA-DR Expression in Colorectal and Gastric Cancer Cells.Oncogene, 23 (55), 8876-8886, 2004.

総説

1. Soejima H, Joh K. and Mukai T. Gene silencing in DNA damage repair. Cell． Mol． Life． Sci． 61, 2168-2172, 2004．
2. 副島英伸、東元健、城圭一郎、向井常博．　non-coding RNAの構造と機能　押村光雄編　注目のエピジェネティクスがわかるゲノムの修飾構造変換と生命の多様性、疾患とのかかわり　羊土社　2004．
3. 副島英伸、東元健、向井常博．Beckwith-Wiedemann 症候群の分子遺伝学、細胞 36, 278-281, 2004．

著書

1. 副島英伸，太田　亨，木住野達也，新川詔夫，向井常博．エピジェネティクスと疾患．４．インプリントドメインの異常と疾患．佐々木裕之：エピジェネティクス．213-220．シュプリンガー・フェアラーク．東京　2004．

原著

1. Nakagawachi T, Soejima H, Urano T, Zhao W, Higashimoto K, Satoh Y, Matsukura S, Kudo S, Kitajima Y, Harada H, Furukawa K, Matsuzaki H, Emi M, Nakabeppu Y, Miyazaki K, Sekiguchi M, Mukai T. Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer. Oncogene 22(55): 8835-8844, 2003
2. Higashimoto K, Urano T, Sugiura K, Yatsuki H, Joh K, Zhao W, Iwakawa M, Ohashi H, Oshimura M, Niikawa N, Mukai T, Soejima H. Loss of CpG methylation is strongly correlated with loss of histone H3 lysine 9 methylation at DMR-LIT1 in patients with Beckwith-Wiedemann syndrome. Am J Hum Genet, 73(4): 948-956, 2003
3. Satoh Y, Nakagawachi T, Nakadate H, Kaneko Y, Masaki Z, Mukai T, Soejima H. Significant reduction of WT1 gene expression possibly due to epigenetic alteration in Wilms' tumor. J Biochem, 133(3): 303-308, 2003
4. Matsukura S, Soejima H, Nakagawachi T, Yakushiji H, Ogawa A, Fukuhara M, Miyazaki K, Nakabeppu Y, Sekiguchi M, Mukai T. CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection. Brit J Cancer, 88(4): 521-529, 2003