小胞体ストレスと動脈硬化
Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat. Med. 15:1383-1391, 2009

Langerhans cell
Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. J. Exp. Med. 206:3089-100, 2009

血液脳関門
Meningococcal Type IV Pili Recruit the Polarity Complex to Cross the Brain Endothelium. Science 325:83-87, 2009

microRNAと癌
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137:1005-1017, 2009

胃の酸性化障害はCa恒常性と骨量に負の影響を与える
Impaired gastric acidification negatively affects calcium homeostasis and bone mass. Nat. Med. 15:674-681, 2009

アルツハイマー病動物モデルにおける脳由来神経栄養因子による神経保護作用
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat. Med. 15:331-337, 2009

Autophagy: その新たな意義
Autophagy regulates lipid metabolism. Nature 458:1131-1135, 2009

エストロゲン依存性およびC-Cケモカイン受容体2依存性経路が骨粗鬆症で破骨細胞の振る舞いを決定する
Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis. Nat. Med. 15:417-424, 2009

脂肪組織の自己分泌、傍分泌的制御−脂肪特異的PLA（AdPLA）の役割−
AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency, Nat. Med. 15:159-168, 2009

NK細胞がもつ獲得免疫的特徴
Adaptive immune features of natural killer cells. Nature 457:557-561, 2009

Transdifferentiation: もう一つの細胞再プログラム
化機構
In vivo reprogramming of adult pancreatic exocrine cells to β-cells. Nature 455:627-632, 2008

細胞外DNA放出による抗菌機能
Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense. Nat. Med. 14:949-953, 2008

ヒト化マウス、その研究例
The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoetin receptor and megakaryopoiesis.
Haematologica. 93:1495-1504, 2008

乾癬様皮膚炎モデルマウス
IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation J. Clin. Invest. 118:597-607, 2008

iPS
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 318:1920-3, 2007

Caspase-1は非古典的分泌経路を制御している
Active caspase-1 is a regulator of unconventional protein secretion. Cell 132:818-831, 2008

がん患者での悪液質の原因
Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1. Nat. Med. 13:1333-1340, 2007

TANK結合キナーゼ1はDNAワクチンに対する自然免疫と適応免疫応答を形づくる
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 451:725-729, 2008

日内リズムの調節機構
CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature 450:1086-1090, 2007

LPSトレランスとその分子機構
Gene-specific control of inflammation byTLR-induced chromatin modifications. Nature 447:972-979, 2007

マウスにおける、肥満による脂肪組織マクロファージ浸潤及びインスリン抵抗性 とオステオポンチンの関係
Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J. Clin. Inves. 117: 2877-2888, 2007

乳癌でマイクロRNA-10ｂによって惹起される腫瘍の浸潤と転移
Tumour invasion and metastasis initiated by microRNA-10b in brest cancer. Nature 449: 682-688, 2007

Cellular senescence
Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317: 803-6, 2007

表皮におけるカスパーゼ14の役割
Caspase-14 protects against epidermal UVB photodamage and water loss. Nat. Cell Biol. 9: 666-74, 2007

慢性リンパ性白血病の発症機序について
Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell 129: 879-90, 2007

Sepsis における apoptosis について
Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB J. 21: 708-19, 2007

脳におけるグルコース代謝と肝における脂質産生との関係
Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins, Nat. Med. 13: 171-18, 2007

DNA脱メチル化におけるGadd45aの役割
Gadd45a promotes epigenetic gene activation by repair-mediated DNA dem ethylation. Nature 445: 671-5, 2007

再生医療の現状
The development of a bioengineered organ germ method. Nat. Method 4(3): 227-30, 2007

インフルエンザウイルスの諸問題
Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human receptors. Nature 444: 378-382, 2006

癌幹細胞の同定とその意義
Identification and expansion of human colon-cancer-initiating cells. Nature 445: 111-115, 2007